Results 121 to 130 of about 3,922 (300)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Analysis and mitigation of PQ disturbances in grid connected system using fuzzy logic based IUPQC. [PDF]

Sci Rep, 2023
Ravi T, Kumar KS, Dhanamjayulu C, Khan B, Rajalakshmi K.   +4 more
europepmc   +1 more source

VOLTAGE SAG MITIGATION USING SUPERCAPACITOR BASED DYNAMIC VOLTAGE RESTORER

International Journal of Research in Engineering and Technology, 2014
One of the major issues in improving power quality in distribution network is the mitigation of voltage sags which is caused by the system faults and adversely affects the sensitive electrical equipments involved in the end user system. End user system includes industrial production processes and large commercial customers.
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Modulation strategy of dynamic voltage restorer based on dual-feedforward active disturbance rejection compound controller

Frontiers in Energy Research
Given the contradiction between compensating speed and compensating overshoot in traditional Proportional Integral (PI) control of Dynamic Voltage Restorer (DVR), A Feedforward compensation-active Disturbance Rejection Control (FC-ADRC) strategy based on
Langchen Huang, Weiling Liu, Ning Zhang, Qingyun Yan, Xinwei Wei   +4 more
doaj   +1 more source

An Investigation of Power Quality Problems in a Remote Mine Site in Papua New Guinea [PDF]

, 2004
Investigation and monitoring of power quality is necessary to maintain accurate operation of sensitive equipment. Electrical power systems of mines with their sophisticated technology will always have a need for monitoring power quality to ensure that ...
Hemetsberger, F. A., Saha, Tapan K.
core  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Fuzzy logic-controlled three-phase dynamic voltage restorer for enhancing voltage stabilization and power quality

International Journal of Electrical Power & Energy Systems
Enhancing power quality (PQ) in electrical distribution systems is vital for maintaining a stable and reliable power supply, especially for sensitive industrial and commercial loads prone to voltage disturbances.
Abu Shufian, Sowrov Komar Shib, Durjoy Roy Dipto, Md Tanvir Rahman, Nasif Hannan, Shaikh Anowarul Fattah   +5 more
doaj   +1 more source