Results 41 to 50 of about 3,589 (264)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Modeling and dynamic analysis of the non-circular gear system of a bucket wheel stacker/reclaimer
AIP Advances, 2018 Non-circular gear systems (NCGSs) are among the most widely used transmission mechanisms in bucket wheel stacker/reclaimers (BWSRs), the performance of which depends greatly on the NCGS dynamic characteristics such as the transmission efficiency, gear ...
Yongliang Yuan +3 more
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IET Control Theory & Applications, 2021 This paper studies the stability of linearly coupled dynamical systems with feedback pinning algorithms. Here, both the coupling matrix and the set of pinned‐nodes are time‐varying, induced by stochastic processes.
Yujuan Han, Wenlian Lu, Tianping Chen
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Estimation of the Fatigue Life of the Front Axle of a Truck
Engineering Transactions, 1992 Problems of dynamical loads and statistical characteristics of stresses in the front axle of a truck were considered. The probability of fatigue damages and the estimation of the fatigue life for various conditions of the vehicle's operation were ...
L. Prochowski
doaj
Loading Dynamics of a Sliding DNA Clamp [PDF]
Angewandte Chemie, 2014 AbstractSliding DNA clamps are loaded at a ss/dsDNA junction by a clamp loader that depends on ATP binding for clamp opening. Sequential ATP hydrolysis results in closure of the clamp so that it completely encircles and diffuses on dsDNA. We followed events during loading of an E. coli β clamp in real time by using single‐molecule FRET (smFRET).
Cho, Won-Ki +4 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
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Успехи физики металлов, 2016 Due to the fact that in the modern metrological database there is no clear methodology for estimating quality of materials under the conditions of shock and high-speed loads, in this work the analysis of dynamic properties of metallic materials at the ...
V. V. Kurylyak, G. I. Khimicheva
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