Results 51 to 60 of about 3,589 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Analytical method of definition of internal forces taking into account the distributed dynamical loads in links of robotic systems and mechanisms with statically indeterminate structures

Вестник КазНУ. Серия математика, механика, информатика, 2016
In this paper the technique of analytical determination of internal forces in links of planar mechanisms and manipulators with statically indeterminate structures taking into account the distributed dynamical loads, a dead weight and the operating ...
S. Zhilkibayeva, M. U. Utenov, K. Utenova   +2 more
doaj  

Review of Response and Damage of Linear and Nonlinear Systems under Multiaxial Vibration

Shock and Vibration, 2014
A review of past and recent developments in multiaxial excitation of linear and nonlinear structures is presented. The objective is to review some of the basic approaches used in the analytical and experimental methods for kinematic and dynamic analysis ...
Ed Habtour, William (Skip) Connon, Michael F. Pohland, Samuel C. Stanton, Mark Paulus, Abhijit Dasgupta   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

NONLINEAR DYNAMICS OF CLOSED CYLINDRICAL SHELLS UNDER THE ACTION OF LOCAL TRANSVERSE LOADS

Structural Mechanics of Engineering Constructions and Buildings, 2010
The closed cylindrical shell finite length under the action of constant at time and alternating local transversal loads in the context of nonlinear classical theory of gentle shells is consider.
V A Krysko, K F Shagivaleev
doaj  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Dynamic Loadings Of Precastretaining Walls

Kirkuk University Journal-Scientific Studies, 2007
The research aims for the selection of a suitable retaining wall amongst two types of precast concrete walls under dynamic loads (wave pressure). The first wall is of a triangular cross section and has the dimensions (3)m (in height) by (2.2) m (in width) by (0.25-0.3) m (in thickness) and the width of piece (1.44) m. The second wall has dimensions of (
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Existence and structure analysis of attractors for new delayed Kirchhoff-type suspension bridge equations under stochastic perturbations with applications

Ain Shams Engineering Journal
This paper investigates the existence and structure of global attractors for a new class of delayed Kirchhoff-type suspension bridge equations under stochastic perturbations. Through the application of infinite-dimensional dynamical system techniques, we
Tahir Ullah Khan, Christine Markarian
doaj   +1 more source