Results 51 to 60 of about 816,574 (293)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Dynamical Constraints on Exoplanets [PDF]
, 2013 Dynamical studies of new exoplanet systems are a critical component of the discovery and characterisation process. Such studies can provide firmer constraints on the parameters of the newly discovered planets, and may even reveal that the proposed ...
Tinney, Chris +9 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
IET Control Theory & Applications, 2021 This paper studies the stability of linearly coupled dynamical systems with feedback pinning algorithms. Here, both the coupling matrix and the set of pinned‐nodes are time‐varying, induced by stochastic processes.
Yujuan Han, Wenlian Lu, Tianping Chen
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Estimation of the Fatigue Life of the Front Axle of a Truck
Engineering Transactions, 1992 Problems of dynamical loads and statistical characteristics of stresses in the front axle of a truck were considered. The probability of fatigue damages and the estimation of the fatigue life for various conditions of the vehicle's operation were ...
L. Prochowski
doaj
Modeling and dynamic analysis of the non-circular gear system of a bucket wheel stacker/reclaimer
AIP Advances, 2018 Non-circular gear systems (NCGSs) are among the most widely used transmission mechanisms in bucket wheel stacker/reclaimers (BWSRs), the performance of which depends greatly on the NCGS dynamic characteristics such as the transmission efficiency, gear ...
Yongliang Yuan +3 more
doaj +1 more source
Loading Dynamics of a Sliding DNA Clamp [PDF]
Angewandte Chemie, 2014 AbstractSliding DNA clamps are loaded at a ss/dsDNA junction by a clamp loader that depends on ATP binding for clamp opening. Sequential ATP hydrolysis results in closure of the clamp so that it completely encircles and diffuses on dsDNA. We followed events during loading of an E. coli β clamp in real time by using single‐molecule FRET (smFRET).
Cho, Won-Ki +4 more
openaire +5 more sources
Numerical analysis of dynamical systems with codimension two singularities [PDF]
, 2009 Páez Chávez JN. Numerical analysis of dynamical systems with codimension two singularities.
Páez Chávez, Joseph Nikolai
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source