Results 101 to 110 of about 333,427 (264)
AND-NOT logic framework for steady state analysis of Boolean network models
, 2012 Finite dynamical systems (e.g. Boolean networks and logical models) have been used in modeling biological systems to focus attention on the qualitative features of the system, such as the wiring diagram.
Buschur, Kristina +5 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Dynamical Modeling of SAURON Galaxies
, 2002 We describe our program for the dynamical modeling of early-type galaxies observed with the panoramic integral-field spectrograph SAURON. We are using Schwarzschild's numerical orbit superposition method to reproduce in detail all kinematical and ...
Bacon, R. +13 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Dynamical modeling of pulsed two-photon interference
New Journal of Physics, 2016 Single-photon sources are at the heart of quantum-optical networks, with their uniquely quantum emission and phenomenon of two-photon interference allowing for the generation and transfer of nonclassical states.
Kevin A Fischer +3 more
doaj +1 more source
Sequences by Metastable Attractors: Interweaving Dynamical Systems and Experimental Data
Frontiers in Applied Mathematics and Statistics, 2017 Metastable attractors and heteroclinic orbits are present in the dynamics of various complex systems. Although their occurrence is well-known, their identification and modeling is a challenging task.
Axel Hutt, Axel Hutt, Peter beim Graben
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
On the History of Ecosystem Dynamical Modeling: The Rise and Promises of Qualitative Models. [PDF]
Entropy (Basel), 2023 Cosme M, Thomas C, Gaucherel C.
europepmc +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source