Results 61 to 70 of about 39,984 (266)

A Discrete Mathematical Modeling of the Influence of Alcohol Treatment Centers on the Drinking Dynamics Using Optimal Control

Journal of Applied Mathematics, 2020
In this paper, we propose a discrete mathematical model that describes the interaction between the classes of drinkers, namely, potential drinkers P, moderate drinkers M, heavy drinkers H, poor heavy drinkers Tp, rich heavy drinkers Tr, and quitters of ...
Bouchaib Khajji, Abderrahim Labzai, Abdelfatah Kouidere, Omar Balatif, Mostafa Rachik   +4 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Dynamics of Immunological Models

Acta Biotheoretica, 2010
We analyse the effect of the regulatory T cells (Tregs) in the local control of the immune responses by T cells. We obtain an explicit formula for the level of antigenic stimulation of T cells as a function of the concentration of T cells and the parameters of the model.
Pinto, A. A., Burroughs, N. J., Ferreira, Miguel, Oliveira , B. M. P. M.   +3 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Improving dynamical climate predictions with machine learning: insights from a twin experiment framework [PDF]

Nonlinear Processes in Geophysics
Systematic errors in dynamical climate models remain a significant challenge to accurate climate predictions, particularly when modeling the nonlinear coupling between the atmosphere and ocean.
Z. He, Z. He, Z. He, J. Brajard, Y. Wang, X. Wang, X. Wang, Z. Shen, Z. Shen   +8 more
doaj   +1 more source

Mathematical Modeling and Analysis of an Alcohol Drinking Model with the Influence of Alcohol Treatment Centers

International Journal of Mathematics and Mathematical Sciences, 2020
In this paper, we present a continuous mathematical model PMHTrTpQ of alcohol drinking with the influence of private and public addiction treatment centers.
Bouchaib Khajji, Abderrahim Labzai, Omar Balatif, Mostafa Rachik   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Flow-Field Modeling and Mixing Mechanisms of the Twin-Shaft Mixers Based on LBM–LES Coupling

Machines
In modern industrial systems, twin-shaft mixers are key units for efficient mixing and reactions; their performance directly affects product quality, production cycle, and energy consumption across the chemical, pharmaceutical, food, and lithium-battery ...
Wentao Zhao, Jianxiong Ye, Lin Li, Gaoan Zheng   +3 more
doaj   +1 more source

Mathematical Modeling and Optimal Control Strategy for a Discrete Time Drug Consumption Model

Discrete Dynamics in Nature and Society, 2020
The aim of this paper is to study and investigate the optimal control strategy of a discrete mathematical model of drug consumption. The population that we are going to study is divided into six compartments: potential drug users, light drug users, heavy
Abderrahim Labzai, Abdelfatah Kouidere, Bouchaib Khajji, Omar Balatif, Mostafa Rachik   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source