Results 71 to 80 of about 333,427 (264)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Improving dynamical climate predictions with machine learning: insights from a twin experiment framework [PDF]

Nonlinear Processes in Geophysics
Systematic errors in dynamical climate models remain a significant challenge to accurate climate predictions, particularly when modeling the nonlinear coupling between the atmosphere and ocean.
Z. He, Z. He, Z. He, J. Brajard, Y. Wang, X. Wang, X. Wang, Z. Shen, Z. Shen   +8 more
doaj   +1 more source

Mathematical Modeling and Optimal Control Strategy for a Discrete Time Drug Consumption Model

Discrete Dynamics in Nature and Society, 2020
The aim of this paper is to study and investigate the optimal control strategy of a discrete mathematical model of drug consumption. The population that we are going to study is divided into six compartments: potential drug users, light drug users, heavy
Abderrahim Labzai, Abdelfatah Kouidere, Bouchaib Khajji, Omar Balatif, Mostafa Rachik   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A New Mathematical Modeling with Optimal Control Strategy for the Dynamics of Population of Diabetics and Its Complications with Effect of Behavioral Factors

Journal of Applied Mathematics, 2020
We propose an optimal control strategy by conducting awareness campaigns for diabetics about the severity of complications of diabetes and the negative impact of an unbalanced lifestyle and the surrounding environment, as well as treatment and ...
Abdelfatah Kouidere, Abderrahim Labzai, Hanane Ferjouchia, Omar Balatif, Mostafa Rachik   +4 more
doaj   +1 more source

Experimental investigations on nonlinear mechanical behaviors of Kevlar tether

Journal of Engineered Fibers and Fabrics, 2023
A Kevlar tether usually exhibits strong nonlinearity in engineering applications, bringing new challenges to the modeling of tether dynamics. The nonlinear mechanical behaviors, including creep behavior, nonlinear stiffness, hysteresis effect, and ...
Ban Wang, Haozheng Li, Juyong Zhang
doaj   +1 more source

Stability of networks of delay-coupled delay oscillators

, 2011
Dynamical networks with time delays can pose a considerable challenge for mathematical analysis. Here, we extend the approach of generalized modeling to investigate the stability of large networks of delay-coupled delay oscillators.
Gross, Thilo, Höfener, Johannes M., Sethia, Gautam C.   +2 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Flow-Field Modeling and Mixing Mechanisms of the Twin-Shaft Mixers Based on LBM–LES Coupling

Machines
In modern industrial systems, twin-shaft mixers are key units for efficient mixing and reactions; their performance directly affects product quality, production cycle, and energy consumption across the chemical, pharmaceutical, food, and lithium-battery ...
Wentao Zhao, Jianxiong Ye, Lin Li, Gaoan Zheng   +3 more
doaj   +1 more source

Modeling the dynamical interaction between epidemics on overlay networks

, 2011
Epidemics seldom occur as isolated phenomena. Typically, two or more viral agents spread within the same host population and may interact dynamically with each other. We present a general model where two viral agents interact via an immunity mechanism as
Antoine Allard, L. Hébert-Dufresne, Laurent Hébert-Dufresne, Louis J. Dubé, Pierre-André Noël, Vincent Marceau   +5 more
core   +1 more source