Results 141 to 150 of about 93,485 (315)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
, 2013 This work presents innovative scientific results on the robust stabilization of constrained uncertain dynamical systems via Lyapunov-based state feedback control.
GRAMMATICO, SERGIO
core
Long-term Dynamical Evolution and Ejection of Near-Earth Asteroids
The Astrophysical JournalLong-term integrations of asteroid orbits with high-accuracy numerical integrators are essential for understanding dynamical evolution and ejection from the solar system, but are computationally expensive.
Chetan Abhijnanam Bora +2 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Do rapidly and non-rapidly intensifying tropical cyclones represent two different dynamical regimes
npj Climate and Atmospheric ScienceRapid intensification (RI) of tropical cyclones (TCs) poses a major challenge in intensity forecasting and is a key contributor to the observed bimodal distribution of cyclone peak intensities. However, it remains unclear whether RI represents a distinct
John L. McBride +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Random Dynamical Systems with Multiplicative Noise [PDF]
The paper considers random economic systems generating nonlinear time series on the positive half-ray R+. Using Liapunov techniques, new conditions for existence, uniqueness and stability of stationary equilibria are obtained.
John Stachurski
core
Cellular Automata Dynamical Systems
, 2012 International audienceWe present recent studies on cellular automata (CAs) viewed as discrete dynamical systems. In the first part, we illustrate the relations between two important notions: subshift attractors and signal subshifts, measure attractors ...
Alberto Dennunzio +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source