Results 171 to 180 of about 170,832 (317)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Preliminary evidence for chaotic signatures in host-microbe interactions

mSystems
Host-microbe interactions constitute dynamical systems that can be represented by mathematical formulations that determine their dynamic nature and are categorized as deterministic, stochastic, or chaotic.
Yehonatan Sella, Nichole A. Broderick, Kaitlin M. Stouffer, Deborah L. McEwan, Frederick M. Ausubel, Arturo Casadevall, Aviv Bergman   +6 more
doaj   +1 more source

Parliamentary roll-call voting as a complex dynamical system: The case of Chile. [PDF]

PLoS One, 2023
Morales-Bader D, Castillo RD, Cox RFA, Ascencio-Garrido C.   +3 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dynamical system of a time-delayed ϕ⁶-Van der Pol oscillator: a non-perturbative approach. [PDF]

Sci Rep, 2023
Moatimid GM, Amer TS.
europepmc   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Bayesian switching linear dynamical system for estimating seizure chronotypes. [PDF]

Proc Natl Acad Sci U S A, 2022
Wang ET, Vannucci M, Haneef Z, Moss R, Rao VR, Chiang S.   +5 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The association between macronutrient intakes and coronavirus disease 2019 (COVID-19) in an Iranian population: applying a dynamical system model. [PDF]

J Health Popul Nutr, 2023
Hafezi SG, Seifi N, Bahari H, Mohammadi M, Ghasemabadi A, Ferns GA, Farkhani EM, Ghayour-Mobarhan M.   +7 more
europepmc   +1 more source

Recombinant dynamical systems

CoRR
We describe a connectionist model that attempts to capture a notion of experience-based problem solving or task learning, whereby solutions to newly encountered problems are composed from remembered solutions to prior problems. We apply this model to the computational problem of \emph{efficient sequence generation}, a problem for which there is no ...
openaire   +2 more sources