Results 1 to 10 of about 27,598 (253)
Bayesian parameter estimation for dynamical models in systems biology. [PDF]
PLoS Computational Biology, 2022 Dynamical systems modeling, particularly via systems of ordinary differential equations, has been used to effectively capture the temporal behavior of different biochemical components in signal transduction networks.
Nathaniel J Linden +2 more
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PyRates-A code-generation tool for modeling dynamical systems in biology and beyond. [PDF]
PLoS Computational Biology, 2023 The mathematical study of real-world dynamical systems relies on models composed of differential equations. Numerical methods for solving and analyzing differential equation systems are essential when complex biological problems have to be studied, such ...
Richard Gast +2 more
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Parameter Synthesis in Nonlinear Dynamical Systems: Application to Systems Biology [PDF]
Journal of Computational Biology, 2010 The dynamics of biological processes are often modeled as systems of nonlinear ordinary differential equations (ODE). An important feature of nonlinear ODEs is that seemingly minor changes in initial conditions or parameters can lead to radically different behaviors.
Gilles Clermont +2 more
exaly +4 more sources
Time-Optimal Adaptation in Metabolic Network Models
Frontiers in Molecular Biosciences, 2022 Analysis of metabolic models using constraint-based optimization has emerged as an important computational technique to elucidate and eventually predict cellular metabolism and growth.
Markus A. Köbis +2 more
doaj +1 more source
Lessons learned from quantitative dynamical modeling in systems biology. [PDF]
PLoS ONE, 2013 Due to the high complexity of biological data it is difficult to disentangle cellular processes relying only on intuitive interpretation of measurements.
Andreas Raue +11 more
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Modular assembly of dynamic models in systems biology [PDF]
PLOS Computational Biology, 2021 It is widely acknowledged that the construction of large-scale dynamic models in systems biology requires complex modelling problems to be broken up into more manageable pieces. To this end, both modelling and software frameworks are required to enable modular modelling.
Michael Pan +3 more
openaire +5 more sources
A Dynamic Interface for Capsaicinoid Systems Biology [PDF]
Plant Physiology, 2009 AbstractCapsaicinoids are the pungent alkaloids that give hot peppers (Capsicum spp.) their spiciness. While capsaicinoids are relatively simple molecules, much is unknown about their biosynthesis, which spans diverse metabolisms of essential amino acids, phenylpropanoids, benzenoids, and fatty acids.
Michael, Mazourek +5 more
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Correction: Bayesian parameter estimation for dynamical models in systems biology.
PLoS Computational Biology, 2023 [This corrects the article DOI: 10.1371/journal.pcbi.1010651.].
Nathaniel J Linden +2 more
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Modelling the crop: From system dynamics to systems biology [PDF]
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2009 There is strong interplant competition in a crop stand for various limiting resources, resulting in complex compensation and regulation mechanisms along the developmental cascade of the whole crop. Despite decades-long use of principles in system dynamics (e.g.
Yin, X., Struik, P.C.
openaire +3 more sources
Dark Type Dynamical Systems: The Integrability Algorithm and Applications
Algorithms, 2022 Based on a devised gradient-holonomic integrability testing algorithm, we analyze a class of dark type nonlinear dynamical systems on spatially one-dimensional functional manifolds possessing hidden symmetry properties and allowing their linearization on
Yarema A. Prykarpatsky +3 more
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