Results 91 to 100 of about 139,067 (282)

System dynamics modelling in systems biology and applications in pharmacology

, 2018
Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
Fernández-de-Cañete-Rodríguez, Francisco Javier, Ramos-Diaz, Juan Carlos, Fernández de Cañete, Rafael   +2 more
openaire   +2 more sources

Principal manifolds and graphs in practice: from molecular biology to dynamical systems

, 2010
We present several applications of non-linear data modeling, using principal manifolds and principal graphs constructed using the metaphor of elasticity (elastic principal graph approach).
ALEXANDER N. GORBAN, ANDREI ZINOVYEV, Gorban A. N., Gorban A. N., Karhunen K., Loève M. M., Melville A. Yu., Ritter H.   +7 more
core   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Conditional Lie-Bäcklund Symmetry Reductions and Exact Solutions of a Class of Reaction-Diffusion Equations

Advances in Mathematical Physics, 2018
The method of conditional Lie-Bäcklund symmetry is applied to solve a class of reaction-diffusion equations ut+uxx+Qxux2+Pxu+Rx=0, which have wide range of applications in physics, engineering, chemistry, biology, and financial mathematics theory.
Xinyang Wang, Junquan Song
doaj   +1 more source

Dynamical System Theory in Biology [PDF]

Journal of Dynamic Systems, Measurement, and Control, 1973
R. Rosen, George Oster
openaire   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Natural Human Mobility Patterns and Spatial Spread of Infectious Diseases

Physical Review X, 2011
We investigate a model for spatial epidemics explicitly taking into account bidirectional movements between base and destination locations on individual mobility networks.
Vitaly Belik, Theo Geisel, Dirk Brockmann   +2 more
doaj   +1 more source