Results 71 to 80 of about 139,067 (282)
Frontiers in Physiology, 2020 At the crossroad between biology and mathematical modeling, computational systems biology can contribute to a mechanistic understanding of high-level biological phenomenon.
Céline Hernandez +4 more
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Controlling complex dynamical systems based on the structure of the networks
Biophysics and Physicobiology, 2023 Progress of molecular biology resulted in the accumulation of information on biomolecular interactions, which are complex enough to be termed as networks.
Atsushi Mochizuki
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, 2014 The nonlinearity of dynamics in systems biology makes it hard to infer them from experimental data. Simple linear models are computationally efficient, but cannot incorporate these important nonlinearities.
Daniels, Bryan C., Nemenman, Ilya
core +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
MCMC Techniques for Parameter Estimation of ODE Based Models in Systems Biology
Frontiers in Applied Mathematics and Statistics, 2019 Ordinary differential equation systems (ODEs) are frequently used for dynamical system modeling in many science fields such as economics, physics, engineering, and systems biology.
Gloria I. Valderrama-Bahamóndez +2 more
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Selection on Network Dynamics Drives Differential Rates of Protein Domain Evolution. [PDF]
PLoS Genetics, 2016 The long-held principle that functionally important proteins evolve slowly has recently been challenged by studies in mice and yeast showing that the severity of a protein knockout only weakly predicts that protein's rate of evolution.
Brian K Mannakee, Ryan N Gutenkunst
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Graphical criteria for positive solutions to linear systems
, 2017 We study linear systems of equations with coefficients in a generic partially ordered ring $R$ and a unique solution, and seek conditions for the solution to be nonnegative, that is, every component of the solution is a quotient of two nonnegative ...
Feliu, Elisenda +2 more
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Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Control of multilayer biological networks and applied to target identification of complex diseases
BMC Bioinformatics, 2019 Background Networks have been widely used to model the structures of various biological systems. The ultimate aim of research on biological networks is to steer biological system structures to desired states by manipulating signals.
Wei Zheng, Dingjie Wang, Xiufen Zou
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