Results 51 to 60 of about 27,598 (253)
Controllability and Observability Criteria for Linear Piecewise Constant Impulsive Systems
Journal of Applied Mathematics, 2012 Impulsive differential systems are an important class of mathematical models for many practical systems in physics, chemistry, biology, engineering, and information science that exhibit impulsive dynamical behaviors due to abrupt changes at certain ...
Hong Shi, Guangming Xie
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The Generic Sensory Automaton (GENSA) for modeling affinity-based dynamics and interactions in biology [PDF]
EPJ Web of ConferencesMathematics and computer science play a pivotal role in modern biology. Dynamical models based on differential equations are particularly adapted to describe dynamic behaviors of many biological processes.
Pastor Dominique +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Frontiers in Physiology, 2020 At the crossroad between biology and mathematical modeling, computational systems biology can contribute to a mechanistic understanding of high-level biological phenomenon.
Céline Hernandez +4 more
doaj +1 more source
Controlling complex dynamical systems based on the structure of the networks
Biophysics and Physicobiology, 2023 Progress of molecular biology resulted in the accumulation of information on biomolecular interactions, which are complex enough to be termed as networks.
Atsushi Mochizuki
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
MCMC Techniques for Parameter Estimation of ODE Based Models in Systems Biology
Frontiers in Applied Mathematics and Statistics, 2019 Ordinary differential equation systems (ODEs) are frequently used for dynamical system modeling in many science fields such as economics, physics, engineering, and systems biology.
Gloria I. Valderrama-Bahamóndez +2 more
doaj +1 more source