Results 61 to 70 of about 139,067 (282)

Controllability and Observability Criteria for Linear Piecewise Constant Impulsive Systems

Journal of Applied Mathematics, 2012
Impulsive differential systems are an important class of mathematical models for many practical systems in physics, chemistry, biology, engineering, and information science that exhibit impulsive dynamical behaviors due to abrupt changes at certain ...
Hong Shi, Guangming Xie
doaj   +1 more source

Organismic Supercategories: I. Proposals for a General Unified Theory of Systems- Classical, Quantum, and Complex Biological Systems.\ud \ud \ud [PDF]

, 1968
The representation of physical and complex biological systems in terms of organismic supercategories was introduced in 1968 by Baianu and Marinescu in the attached paper which was published in the Bulletin of Mathematical Biophysics, edited by Nicolas ...
Baianu, Prof. Dr. I.C., Marinescu, Dr. Mircea M.   +1 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Generic Sensory Automaton (GENSA) for modeling affinity-based dynamics and interactions in biology [PDF]

EPJ Web of Conferences
Mathematics and computer science play a pivotal role in modern biology. Dynamical models based on differential equations are particularly adapted to describe dynamic behaviors of many biological processes.
Pastor Dominique, Fernandez Jonas, Thomas-Vaslin Véronique   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mathematical and Statistical Techniques for Systems Medicine: The Wnt Signaling Pathway as a Case Study

, 2015
The last decade has seen an explosion in models that describe phenomena in systems medicine. Such models are especially useful for studying signaling pathways, such as the Wnt pathway.
A Gelman, A Saltelli, AC Babtie, AG Fletcher, AL MacLean, AL MacLean, AR Hernández, B Alberts, B Carlin, B Lloyd-Lewis, BR Henderson, CW Gardiner, CW Tan, CW Tan, CY Logan, D Brewer, D Cox, D Kim, E Feliu, E Lee, ER Barry, F Cong, G Craciun, G Craciun, G Craciun, GR Mirams, H Clevers, H Kitano, HA Harrington, I Ramis-Conde, IMM Leeuwen van, J Franca-Koh, J Heuberger, J Jost, J Liepe, J Liepe, J Neumann von, J Stark, J Stelling, J. Kevorkian, K Itoh, KH Cho, L Goentoro, L Vermeulen, M Basan, M Beguerisse-Díaz, M Feinberg, M Feinberg, M Kuhl, M Secrier, M Sunnåker, N Blüthgen, N Gershenfeld, N Gilbert, N Wiechens, O Ratmann, P Buske, P Glendinning, P Kirk, P Polakis, PJ Murray, PJ Murray, R Habas, R Krüger, RN Gutenkunst, S Wolfram, T Reya, T Toni, VSW Li, X Varelas, Y Kogan, Y Schmitz, Y Schmitz, Y Zhou   +73 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Function of dynamic models in systems biology: linking structure to behaviour [PDF]

Journal of Biomedical Semantics, 2013
Dynamic models in Systems Biology are used in computational simulation experiments for addressing biological questions. The complexity of the modelled biological systems and the growing number and size of the models calls for computer support for modelling and simulation in Systems Biology.
Knüpfer, Christian, Beckstein, Clemens
openaire   +2 more sources

Reproducing kernel Hilbert space based estimation of systems of ordinary differential equations

, 2014
Non-linear systems of differential equations have attracted the interest in fields like system biology, ecology or biochemistry, due to their flexibility and their ability to describe dynamical systems.
González, Javier, Vujačić, Ivan, Wit, Ernst   +2 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source