Results 81 to 90 of about 27,598 (253)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Dynamical systems foundations for neuromorphic intelligence

Neuromorphic Computing and Engineering
Neuromorphic computing seeks to replicate the remarkable efficiency, flexibility, and adaptability of the human brain in artificial systems. Unlike conventional digital approaches, which suffer from the Von Neumann bottleneck and depend on massive ...
Marcel van Gerven
doaj   +1 more source

Dynamical System Theory in Biology [PDF]

Journal of Dynamic Systems, Measurement, and Control, 1973
R. Rosen, George Oster
openaire   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Quantitative Biology: Dynamics of Living Systems

, 2017
With the emergence of Systems Biology, there is a greater realization that the whole behavior of a living system may not be simply described as the sum of its elements. To represent a living system using mathematical principles, practical quantities with units are required.
Noriko Hiroi, Douglas B. Murray, Viji M. Draviam, Chun-Biu Li, Hiroaki Takagi, Ziya Kalay, Tetsuya J. Kobayashi, Akira Funahashi, Akatsuki Kimura, Rinshi S. Kasai, Naoki A. Irie, Jason Edward Shoemaker   +11 more
openaire   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Correction: Lessons Learned from Quantitative Dynamical Modeling in Systems Biology.

PLoS ONE, 2013
Andreas Raue, Marcel Schilling, Julie Bachmann, Andrew Matteson, Max Schelker, Daniel Kaschek, Sabine Hug, Clemens Kreutz, Brian D. Harms, Fabian J. Theis, Ursula Klingmüller, Jens Timmer   +11 more
doaj   +3 more sources

SMART: spatial multi-omic aggregation using graph neural networks and metric learning

Nature Communications
Spatial multi-omics enables the exploration of tissue microenvironments and heterogeneity from the perspective of different omics modalities across distinct spatial domains within tissues.
Zhihua Du, Qiyi Chen, Weiliang Huang, Jinmiao Chen, Xubin Zheng   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source