Results 131 to 140 of about 1,894,382 (325)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

open access: yesMolecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau   +9 more
wiley   +1 more source

GDSCalc: A Web-Based Application for Evaluating Discrete Graph Dynamical Systems.

open access: yesPLoS ONE, 2015
Discrete dynamical systems are used to model various realistic systems in network science, from social unrest in human populations to regulation in biological networks.
Sherif H Elmeligy Abdelhamid   +4 more
doaj   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

open access: yesFEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui   +15 more
wiley   +1 more source

Dynamical Systems on Bundles [PDF]

open access: yesarXiv, 2009
In this study, Hamiltonian and Lagrangian theories, which are mathematical models of mechanical systems, are structured on the horizontal and the vertical distributions of tangent and cotangent bundles. In the end, the geometrical and physical results related to Hamiltonian and Lagrangian dynamical systems are concluded.
arxiv  

Theory for dynamical short-range order and Fermi surface volume in strongly correlated systems [PDF]

open access: green, 1996
Jörg Schmalian   +3 more
openalex   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

open access: yesFEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren   +8 more
wiley   +1 more source

Bifurcation, chaotic behavior, and traveling wave solutions of the space–time fractional Zakharov–Kuznetsov–Benjamin–Bona–Mahony equation

open access: yesFrontiers in Physics
The space–time fractional Zakharov–Kuznetsov–Benjamin–Bona–Mahony (ZKBBM) equation is a significant nonlinear model used to illustrate numerous physical phenomena, such as water wave mechanics, fluid flow, marine and coastal science, and control systems.
Shan Zhao, Zhao Li
doaj   +1 more source

Computational Dynamical Systems [PDF]

open access: yesarXiv
We study the computational complexity theory of smooth, finite-dimensional dynamical systems. Building off of previous work, we give definitions for what it means for a smooth dynamical system to simulate a Turing machine. We then show that 'chaotic' dynamical systems (more precisely, Axiom A systems) and 'integrable' dynamical systems (more generally,
arxiv  

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