Results 41 to 50 of about 337,081 (267)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Robot Simulation on Agri-Field Point Cloud With Centimeter Resolution

IEEE Access
The need for robotic agricultural automation has been driven by global population growth and climate change.To efficiently evaluate and develop agricultural robots not limited to the growing season, we developed a dynamics simulator that works fast on 3D
Shintaro Noda, Masayuki Kogoshi, Wataru Iijima   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Experimental Verification of the Steering Performance of All-Hydraulic Crawler Chassis

Engineering Transactions, 2018
The force conditions in the steering system of the chassis under different conditions are analyzed theoretically for the independently designed and developed all-hydraulic crawler chassis.
Xiaolian LV, Xiaorong LV, Xiaojie SHI, Tingyu WANG   +3 more
doaj   +1 more source

Addendum to "A generalized Nash equilibrium for a bio-economic problem of fishing" [PDF]

Journal of Applied Research on Industrial Engineering, 2017
In [1] the authors have set up a bio-economic equilibrium model to understand the interactions between three fish populations and seek to maximize the profits of fishermen.
Imane Agmour, Naceur Achtaich, Youssef EL Foutayeni, Mohamed Khaladi, Abdelmounaim Zegzouti   +4 more
doaj   +1 more source

Expression Pattern and Ligand Binding Characteristics Analysis of Chemosensory Protein SnitCSP2 from Sirex nitobei

Insects, 2023
Sirex nitobei is an important wood-boring wasp to conifers native to Asia, causing considerable economic and ecological damage. However, the current control means cannot achieve better efficiency, and it is expected to clarify the molecular mechanism of ...
Pingping Guo, Enhua Hao, Han Li, Xi Yang, Pengfei Lu, Haili Qiao   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Kinetic measurements of membrane target level and on-cell binding of biotherapeutic antibodies using flow-cytometry

AAPS Open
Characterization of cell surface target expression is critical for the development of therapeutics that bind membrane proteins or use changes in target abundance as efficacy biomarkers.
Daniel T. Doty, Mahua Roy, Phanidhar Kukutla, Nicholas Lucarelli, Peter E. Struss, Lindsay E. King, Jeffrey R. Chabot, Jatin Narula, Hendrik Neubert, Polina Goihberg   +9 more
doaj   +1 more source

Efficacy of Mini Wheel-Driven Sweet Potato Transplanting Machine for Mulched Raised Beds

Agriculture
The mechanized transplanting of sweet potato slips onto mulched raised beds in China’s Huang-Huai-Hai region faces significant challenges due to fragmented smallholder farms and the specific agronomic requirement of “boat-shaped” horizontal planting.
Tengfei He, Hu Liu, Yupeng Shi, Baoqing Wang, Hui Li, Xiuwen Zhang, Song Shi   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source