Results 61 to 70 of about 337,081 (267)

Dynamics Performance Research and Calculation of Speed Threshold Curve for High-Speed Trains Under Unsteady Wind Loads

Mathematics
Affected by strong wind environments, the vibration of trains will significantly intensify, which will severely impact the running quality of trains. To address such challenges, an improved wind load model is proposed in this paper to simulate the shock ...
Gaoyang Meng, Jianjun Meng
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Simulation of Hydrate Dynamics in Reservoirs [PDF]

International Petroleum Technology Conference, 2011
Abstract Gas hydrates in reservoirs are generally not in thermodynamic equilibrium and there may be several competing phase transitions involving hydrate. Formation of carbon dioxide hydrates during aquifer storage of carbon dioxide involves roughly 10% volume increase compared to groundwater.
Kvamme, Bjørn, Vafaei, Mohammad Taghi, Chejara, Ashok, Jemai, Khaled   +3 more
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Optimization Analysis of Catwalk Structure for Offshore Workover Based on Response Surface Methodology

Shiyou jixie, 2023
The space and rated load-bearing capacity of the offshore platform are both limited,and the currently available power catwalk presents the disadvantages of relatively low overall quality and an excessively large footprint.A completely hydraulicallz ...
Pei Xueliang, Li Jinfu, Zhang Xianwei, Liu Yousheng, Gao Yu   +4 more
doaj  

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Conformational Dynamics Simulations of Proteins [PDF]

, 1999
Molecular dynamics (MD) simulations of proteins provide descriptions of atomic motions, which allow to relate observable properties of proteins to microscopic processes. Unfortunately, such MD simulations require an enormous amount of computer time and, therefore, are limited to time scales of nanoseconds.
Eichinger, Markus, Heymann, Berthold, Heller, Helmut, Grubmüller, Helmut, Tavan, Paul, Hermans, J., Deuflhard, P., Mark, A. E., Leimkuhler, B., Reich, S., Skeel, R. D.   +10 more
openaire   +2 more sources

3D Modeling Simulation and Innovative Design of a Saw Cutting Mechanism for a Movable Buckling Machine

Applied Sciences
In this research, a sawing mechanism of a mobile buckling machine was innovatively designed for the forest resources and environmental characteristics of the northeast region of China.
Xuechun Yang, Xiangjie Wu, Huadong Xu
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source