Results 1 to 10 of about 11,182 (207)

Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor [PDF]

Nature Communications
The endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li, Nathan D. Winters, Shubhi Pandey, Colten Lankford, Hannah M. Stoveken, Emery Smith, Chu-Ting Chang, Stefano Zucca, Louis Scampavia, Timothy Spicer, Kirill A. Martemyanov   +10 more
doaj   +2 more sources

Microiontophoretic Application of Dynorphin in Dental Pain: Excitatory or Inhibitory Effects [PDF]

Journal of Pain Research
Seung-Ho Choi,* Yu-Mi Kim,* Jo-Young Son, Dong-Kuk Ahn Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea*These authors contributed equally to this workCorrespondence: Dong-Kuk Ahn, Department of ...
Choi SH, Kim YM, Son JY, Ahn DK
doaj   +2 more sources

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

eLife, 2021
Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Manojkumar A Puthenveedu   +4 more
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Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep

Biology, 2021
The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts, KaLynn Harlow, Max J. Griesgraber, Elizabeth C. Bowdridge, Steven L. Hardy, Casey C Nestor, Stanley M. Hileman   +6 more
doaj   +1 more source

SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]

BAG. Journal of Basic and Applied Genetics, 2020
Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F., Castellote M.A., Corva P.M.   +2 more
doaj   +1 more source

Distribution and regulation of gonadotropin-releasing hormone, kisspeptin, RF-amide related peptide-3, and dynorphin in the bovine hypothalamus [PDF]

PeerJ, 2016
Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus (ARC) play a key role in gonadotropin-releasing hormone (GnRH) pulse generation and gonadal steroid feedback, with kisspeptin driving GnRH ...
Valeria M. Tanco, Brian K. Whitlock, Melaney A. Jones, Robyn R. Wilborn, Terry D. Brandebourg, Chad D. Foradori   +5 more
doaj   +2 more sources

Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway

Cell & Bioscience, 2020
Background Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating ...
Lin Liu, Yingtong Xu, Hongmei Dai, Shan Tan, Xiao Mao, Zhiheng Chen   +5 more
doaj   +1 more source

Viral risk factor for seizures: Pathobiology of dynorphin in herpes simplex viral (HSV-1) seizures in an animal model

Neurobiology of Disease, 2006
Up to 89% of patients with herpes simplex virus type-1 (HSV-1) encephalitis can have seizures. Possibly, viruses are environmental triggers for seizures in genetically vulnerable individuals. Inherited dynorphin promoter polymorphisms are associated with
Marylou V. Solbrig, Russell Adrian, Daniel Y. Chang, Guey-Chuen Perng   +3 more
doaj   +1 more source

Dynorphin, stress, and depression [PDF]

Brain Research, 2010
Stress is most often associated with aversive states. It rapidly induces the release of hormones and neuropeptides including dynorphin, which activates kappa opioid receptors (KORs) in the central and peripheral nervous systems. In animal models, many aversive effects of stress are mimicked or exacerbated by stimulation of KORs in limbic brain regions.
Allison T, Knoll, William A, Carlezon
openaire   +2 more sources

The Opioid Peptide Dynorphin a Induces Leukocyte Responses via Integrin Mac-1 (αβ, CD11b/CD18)

Molecular Pain, 2015
Background Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production. The mechanisms
Nataly P. Podolnikova, Julie A. Brothwell, Tatiana P. Ugarova   +2 more
doaj   +1 more source