Results 21 to 30 of about 11,182 (207)
Dynorphin is expressed primarily by GABAergic neurons that contain galanin in the rat dorsal horn
Molecular Pain, 2011 Background The opioid peptide dynorphin is expressed by certain neurons in the superficial dorsal horn of the spinal cord, but little is known about the types of cell that contain dynorphin.
Kaneko Takeshi +6 more
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Dynorphin and the pathophysiology of drug addiction [PDF]
Pharmacology & Therapeutics, 2007 Drug addiction is a chronic relapsing disease in which drug administration becomes the primary stimulus that drives behavior regardless of the adverse consequence that may ensue. As drug use becomes more compulsive, motivation for natural rewards that normally drive behavior decreases. The discontinuation of drug use is associated with somatic signs of
T S, Shippenberg, A, Zapata, V I, Chefer
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Frontiers in Pharmacology, 2016 Aconitines, including bulleyaconitine A, probably the most bioactive and abundant alkaloids in Aconitum plant, are a group of diester C19-diterpenoid alkaloids with one acetylester group attached to C8 of the diterpenoid skeleton and one benzoylester ...
Teng-Fei Li, Yong-Xiang Wang, Nian Gong
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Estradiol treatment prevents injury induced enhancement in spinal cord dynorphin expression.
Frontiers in Physiology, 2012 Administration of the ovarian steroid estradiol in male and female animals has been shown to have neuromodulatory and neuroprotective effects in a variety of experimental models. In the present study, spinal tissues from dermatomes just above (T5-7, at
Daya S. Gupta, Charles H. Hubscher
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Frontiers in Pharmacology, 2021 The kappa-opioid receptor (KOR) / dynorphin system is implicated with behavioral and neurobiological effects of stress exposure (including heavy exposure to drugs of abuse) in translational animal models.
Caroline Baynard +2 more
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Neurobiology of Disease, 2001 Opioid receptor-binding autoradiography was used as a way to map sites of altered opioid transmission in a rat model of l-DOPA-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathways sustained a 3-week treatment ...
P.A. Johansson +3 more
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions
Molecular MetabolismObjective: Dynorphin, an endogenous opioid peptide predominantly expressed in the central nervous system and involved in stress response, pain, and addiction, has intrigued researchers due to its expression in pancreatic β-cells.
Miranda Movahed +2 more
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eLife, 2016 Kisspeptin (Kiss1) and neurokinin B (NKB) neurocircuits are essential for pubertal development and fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (Kiss1ARH) co-express Kiss1, NKB, dynorphin and glutamate and are postulated to provide ...
Jian Qiu +6 more
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Journal of Functional Morphology and Kinesiology, 2022 Physical activity (PA) is a non-invasive, cost-effective means of reducing chronic disease. Most US citizens fail to meet PA guidelines, and individuals experiencing chronic stress are less likely to be physically active.
Kolter B. Grigsby +5 more
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Functional Characterization of Spinocerebellar Ataxia Associated Dynorphin A Mutant Peptides
Biomedicines, 2021 Mutations in the prodynorphin gene (PDYN) are associated with the development of spinocerebellar ataxia type 23 (SCA23). Pathogenic missense mutations are localized predominantly in the PDYN region coding for the dynorphin A (DynA) neuropeptide and lead ...
Andreas Lieb +6 more
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