Results 11 to 20 of about 11,182 (207)

Dynorphin-induced neurotoxicity in the mammalian spinal cord.

open access: yes, 1988
Dynorphin-induced neurotoxicity in the mammalian spinal ...
Robert Martin. Caudle (7988414)
core   +6 more sources

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

open access: yes, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J.   +6 more
core   +1 more source

Dissecting the Roles of GABA and Neuropeptides from Rat Central Amygdala CRF Neurons in Anxiety and Fear Learning

open access: yesCell Reports, 2019
Summary: Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF neurons release GABA and several neuropeptides predicted to play important yet opposing roles in these behaviors ...
Matthew B. Pomrenze   +5 more
doaj   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

open access: yesFrontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama   +4 more
doaj   +1 more source

Traumatic Stress-Induced Vulnerability to Addiction: Critical Role of the Dynorphin/Kappa Opioid Receptor System

open access: yesFrontiers in Pharmacology, 2022
Substance use disorders (SUD) may emerge from an individual’s attempt to limit negative affective states and symptoms linked to stress. Indeed, SUD is highly comorbid with chronic stress, traumatic stress, or post-traumatic stress disorder (PTSD), and ...
Claire Leconte   +2 more
doaj   +1 more source

Actions of D-Ala2-D-Leu5-enkephalin and dynorphin A (1–17) on neocortical neurons in vitro [PDF]

open access: yes, 1984
Intracellular recordings were made from neocortical neurons in vitro. Application of D-Ala2-D-Leu5-enkephalin (DADL) by different methods produced a decrease in EPSP amplitude and in the amplitude of L-glutamate-induced depolarizations without changes in
Zieglgänsberger, Walter, Sutor, Bernd
core   +1 more source

Nonopioid actions of dynorphin and neuropathic pain

open access: yes, 2000
The hypothesis of this dissertation is that peripheral nerve injury will elevate dynorphin in the spinal cord, which has a facilitating effect on the nociceptive pathway via a non-opioid mechanism.
Tang, Qingbo
core   +4 more sources

Endogenous Opioids in Crohn’s Disease

open access: yesBiomedicines, 2023
Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak   +2 more
doaj   +1 more source

CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior.

open access: yesPLoS ONE, 2009
Stress is a complex human experience and having both rewarding and aversive motivational properties. The adverse effects of stress are well documented, yet many of underlying mechanisms remain unclear and controversial. Here we report that the anxiogenic
Michael R Bruchas   +3 more
doaj   +1 more source

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