Results 1 to 10 of about 1,463,708 (228)
The kappa opioid receptor: from addiction to depression, and back [PDF]
Frontiers in Psychiatry, 2014 Comorbidity is a major issue in psychiatry that notably associates with more severe symptoms, longer illness duration and higher service utilization.
Laurence eLalanne +3 more
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The Kappa Opioid Receptor: Candidate Pharmacotherapeutic Target for Multiple Sclerosis
Drugs and Drug Candidates, 2023 Multiple sclerosis (MS) afflicts millions of people worldwide. While multiple therapeutics have recently been developed and approved as treatment agents, they are not 100% effective.
Brian Reed, Surya Dutta
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IUPHAR themed review: Opioid efficacy, bias, and selectivity
Pharmacological Research, 2023 Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain, though they represent the second line of treatment behind GABA analogs, antidepressants and SSRI’s.
Nokomis Ramos-Gonzalez +2 more
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Frontiers in Pharmacology, 2023 Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit ...
Rink-Jan Lohman +4 more
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The opioid receptor: emergence through millennia of pharmaceutical sciences
Frontiers in Pain Research, 2023 Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review reflects upon the conceptualization of the opioid receptor and the critical role that the ...
Carolyn A. Fairbanks +4 more
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Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors
Pharmaceuticals, 2022 The delta opioid receptor is a Gi-protein-coupled receptor (GPCR) with a broad expression pattern both in the central nervous system and the body. The receptor has been investigated as a potential target for a multitude of significant diseases including ...
Yazan J. Meqbil, Richard M. van Rijn
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Nanobody-enabled monitoring of kappa opioid receptor states
Nature Communications, 2020 Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized states ...
Tao Che +13 more
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Ascent of the kappa-opioid receptor in psychopharmacology [PDF]
Psychopharmacology, 2010 Often overshadowed by other members of the endogenous opioid receptor family, kappa-opioid receptors (KORs) are rapidly emerging as an important target for the study and treatment of a variety of central nervous system disorders. This Special Issue is dedicated to 18 papers that describe some of the newest and most important developments.
William A, Carlezon, Klaus A, Miczek
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Frontiers in Pharmacology, 2020 Opioids are the most effective analgesics used in the clinical management of cancer pain or non-cancer pain. However, chronic opioids therapy can cause many side effects including respiratory depression, nausea, sedation, itch, constipation, analgesic ...
Li Zhang +4 more
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