Results 41 to 50 of about 1,463,708 (228)

Does the kappa opioid receptor system contribute to pain aversion?

Frontiers in Pharmacology, 2014
The kappa opioid receptor (KOR) and the endogenous peptide-ligand dynorphin have received significant attention due the involvement in mediating a variety of behavioral and neurophysiological responses, including opposing the rewarding properties of ...
Catherine M Cahill, Catherine M Cahill, Catherine M Cahill, Anna MW Taylor, Anna MW Taylor, Christopher P Cook, Edmund W Ong, Edmund W Ong, Jose A Moron, Christopher J Evans   +9 more
doaj   +1 more source

Semisynthetic neoclerodanes as kappa opioid receptor probes [PDF]

Bioorganic & Medicinal Chemistry, 2012
Modification of the furan ring of salvinorin A (1), the main active component of Salvia divinorum, has resulted in novel neoclerodane diterpenes with opioid receptor affinity and activity. Conversion of the furan ring to an aldehyde at the C-12 position (5) has allowed for the synthesis of analogues with new carbon-carbon bonds at that position ...
Lovell, Kimberly M., Vasiljevik, Tamara, Araya, Juan Jose, Lozama, Anthony, Prevatt-Smith, Katherine M., Day, Victor W., Dersch, Christina M., Rothman, Richard B., Butelman, Eduardo R., Kreek, Mary Jeanne, Prisinzano, Thomas E.   +10 more
openaire   +3 more sources

Therapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model

Annals of Neurology, EarlyView.
Narcolepsy type 1 is characterized by cataplexy, for which current treatments targeting monoaminergic, histaminergic, and GABAergic pathways may be ineffective or poorly tolerated. We report the case of a 34‐year‐old man with narcolepsy type 1, intolerant to standard therapies, who experienced marked and sustained cataplexy reduction with morning ...
Francois Ricordeau, Sebastien Arthaud, Leila Langbour, Silvia Melzi, Aurelie Richard‐Mornas, Hannah Doudoux, Benjamin Rolland, Laure Peter‐Derex, Christelle Peyron   +8 more
wiley   +1 more source

Kappa Opioid Regulation of Stress-Related Behavior [PDF]

, 2010
Anxiety disorders affect roughly 40 million American adults in a given year. Those suffering from anxiety disorders often experience additional stress-linked illnesses, such as depression.
Harshberger, Erin
core  

The Kappa Opioid Receptor: A Promising Therapeutic Target for Multiple Pathologies

Frontiers in Pharmacology, 2022
Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system, where they modulate a range of physiological processes depending on their location, including stress, mood, reward, pain, inflammation, and remyelination.
Martin L. Dalefield, Brittany Scouller, Rabia Bibi, Bronwyn M. Kivell   +3 more
doaj   +1 more source

The Role of Opioids on Motor Activity in Physio-pathological Conditions [PDF]

, 2009
To date, four principal classes of opioid peptide receptors, μ (MOP), κ (KOP), δ (DOP) and ORL- 1 (NOP) have been identified and cloned. The experimental and clinical importance of this receptor family has been amply demonstrated in many diseases ...
Mabrouk, Omar Sharif
core  

Molecular docking study of Papaver alkaloids to some alkaloid receptors [PDF]

Research Journal of Pharmacognosy, 2017
Background and objectives: More than 40 different alkaloids have been obtained from opium the most important of which are morphine, codeine, papaverine, noscapine and tabaine.
A. Nofallah, Sh. Hooshmand*, M. Gholami, M. Piri   +3 more
doaj  

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

Arthritis &Rheumatology, Accepted Article.
Objectives The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing (RNAseq) in vastus lateralis muscle, resulting in 523 participants (56% female ...
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

RETRACTED ARTICLE: Down-regulation of kappa opioid receptor promotes ESCC proliferation, invasion and metastasis via the PDK1-AKT signaling pathway

Cell Communication and Signaling, 2022
Background As a class of the opioid receptors, the kappa opioid receptor (KOR) has been verified to be a potential biomarker and therapeutic target for human malignant tumors.
Han-Ming Huang, Xin-Hua He, Xiao-Yu Huang, Guo-Yun Wang, Qiao-Xi Xia, Ze-Peng Du, Yong-Fa Zhang   +6 more
doaj   +1 more source

Kappa-opioid receptor activation reinstates nicotine self-administration in mice

Addiction Neuroscience, 2022
Voluntary drug administration is a key facet of substance use disorder (SUD). Among the substances included under SUD, nicotine is the leading cause of preventable death. Nicotine use is also particularly sensitive to relapse, with stress being the major
Raajaram Gowrishankar, Adrian Gomez, Marie Waliki, Michael R. Bruchas   +3 more
doaj   +1 more source