Results 31 to 40 of about 1,463,708 (228)
Receptores de dopamina y heterómeros de receptores de dopamina en la modulación de la neurotransmisión [PDF]
, 2012 [spa] La mayoría de los ligandos de GPCR que actúan como agonistas, antagonistas o agonistas inversos, se unen al mismo dominio del receptor reconocido por los agonistas endógenos, es decir, el lugar de unión ortostérico.
González González, Sergio
core +6 more sources
Journal of Pharmacological Sciences, 2015 In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed
Hitomi Higuchi +4 more
doaj +1 more source
Neurons derived from human-induced pluripotent stem cells express mu and kappa opioid receptors
Neural Regeneration Research, 2021 Neuroprotection studies have shown that induced pluripotent stem (iPS) cells have the possibility to transform neuroprotection research. In the present study, iPS cells were generated from human renal epithelial cells and were then differentiated into ...
Zhi-Hai Ju +5 more
doaj +1 more source
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
BJA Open, 2023 Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors.
David G. Lambert
doaj +1 more source
Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor.
Justyna Piekielna-Ciesielska +7 more
doaj +1 more source
Pharmacology of Kappa Opioid Receptors: Novel Assays and Ligands
Frontiers in Pharmacology, 2022 The present study investigated the in vitro pharmacology of the human kappa opioid receptor using multiple assays, including calcium mobilization in cells expressing chimeric G proteins, the dynamic mass redistribution (DMR) label-free assay, and a ...
Chiara Sturaro +11 more
doaj +1 more source
The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review
Pharmacy, 2022 The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses.
Colleen G. Jordan +5 more
doaj +1 more source
Behavioral meaningful opioidergic stimulation activates kappa receptor gene expression
Brazilian Journal of Medical and Biological Research, 2012 The periaqueductal gray (PAG) has been reported to be a location for opioid regulation of pain and a potential site for behavioral selection in females.
E. Teodorov +4 more
doaj +2 more sources
Role of Opioid Ligands in the Irritable Bowel Syndrome
Canadian Journal of Gastroenterology, 1999 Endogenous opioid peptides – enkephalins, beta-endorphin and dynorphins – are located in specific sites of the brain, the spinal cord, the autonomic ganglia and the enteric nervous system.
Enrico Corazziari
doaj +1 more source