Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction [PDF]
Frontiers in Endocrinology, 2021 Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama +4 more
doaj +2 more sources
Essential Role of Histidine for Rapid Copper(II)-Mediated Disassembly of Neurokinin B Amyloid [PDF]
Biomolecules, 2022 Neurokinin B is a tachykinin peptide involved in a diverse range of neuronal functions. It rapidly forms an amyloid, which is considered physiologically important for efficient packing into dense core secretory vesicles within hypothalamic neurons ...
Bhawantha M. Jayawardena +3 more
doaj +2 more sources
Assessing the effects of menopause and obesity on matriptase-2 and neurokinin B concentrations: A cross-sectional study [PDF]
Journal of Medical BiochemistryBackground: Matriptase-2 (MT2) is implicated in iron metabolism, obesity, insulin resistance, and glucose homeostasis. Neurokinin B (NKB) plays a crucial role in gonadotropin secretion, which is essential for reproduction.
Bulut Arikan Funda, Sagsoz Nevin
doaj +2 more sources
Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats [PDF]
The Journal of Reproduction and Development, 2021 Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic gonadotropin-releasing hormone (GnRH) pulse generator.
Yoshihiro WAKABAYASHI +2 more
doaj +2 more sources
Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes in vitro [PDF]
Journal of Veterinary ResearchNeurokinin B (NKB), dynorphin A (Dyn A) and kisspeptin (KiSS) are key agents that participate in the neuroendocrine regulation of the development and functioning of the reproductive system.
Szysiak Natalia +5 more
doaj +2 more sources
Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep [PDF]
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
doaj +2 more sources
The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.
Endocr Rev, 2023 Abstract Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding ...
Patel B +6 more
europepmc +3 more sources
Neurokinin B and pre-eclampsia: a decade of discovery [PDF]
Reproductive Biology and Endocrinology, 2010 At the start of the last decade, we provided evidence that levels of the peptide neurokinin B were highly elevated in pre-eclampsia. We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain
Page Nigel M
doaj +4 more sources
Influence of neurokinin B, dynorphin A and kisspeptin-10 on in vitro gonadotropin secretion by anterior pituitary cells isolated from pubescent ewes [PDF]
Journal of Veterinary ResearchThe hypothalamic neuropeptides kisspeptin-10 (KiSS-10), neurokinin B (NKB), and dynorphin A (Dyn A) play roles in the endocrine regulation of the hypothalamic–pituitary–ovarian (HPO) axis in puberty.
Szysiak Natalia +7 more
doaj +2 more sources
Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment [PDF]
Diagnostics, 2021 Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs.
Shoko Yoshida +9 more
doaj +2 more sources