Results 1 to 10 of about 402 (139)

Malnutrition Alters Protein Expression of KNDy Neuropeptides in the Arcuate Nucleus of Mature Ewes [PDF]

Frontiers in Physiology
The neuropeptides kisspeptin, neurokinin B, and dynorphin A are imperative for the pulsatile secretion of gonadotropin-releasing hormone and luteinizing hormone to ultimately regulate reproductive cyclicity.
Jennifer F. Thorson, Ligia D. Prezotto
exaly   +6 more sources

Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron [PDF]

eLife, 2021
The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out
Xinhuai Liu, Shel-Hwa Yeo, H James McQuillan, Michel K Herde, Sabine Hessler, Isaiah Cheong, Robert Porteous, Allan E Herbison   +7 more
doaj   +6 more sources

Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats

The Journal of Reproduction and Development, 2021
Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic gonadotropin-releasing hormone (GnRH) pulse generator.
Yoshihiro WAKABAYASHI, Hiroaki OKAMURA, Takashi YAMAMURA   +2 more
doaj   +1 more source

Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

eLife, 2021
Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH release.
Margaritis Voliotis, Xiao Feng Li, Ross Alexander De Burgh, Geffen Lass, Deyana Ivanova, Caitlin McIntyre, Kevin O'Byrne, Krasimira Tsaneva-Atanasova   +7 more
doaj   +1 more source

Research progress of the role of Kisspeptin in puberty onset [PDF]

Jichu yixue yu linchuang, 2022
Kisspeptin activates the hypothalamic-pituitary-gonadal axis (HPGA) and regulates the pulsatile secretion of gonadotropin-releasing hormone (GnRH) through KNDy neurons, thereby regulating the initiation of the pubertal phase.
ZHAO Zi-jun, MA Wei
doaj   +1 more source

A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male mice

eLife, 2021
GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (KNDy neurons) are considered the main regulator of GnRH output.
Charlotte Vanacker, R Anthony Defazio, Charlene M Sykes, Suzanne M Moenter   +3 more
doaj   +1 more source

Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep

Biology, 2021
The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts, KaLynn Harlow, Max J. Griesgraber, Elizabeth C. Bowdridge, Steven L. Hardy, Casey C Nestor, Stanley M. Hileman   +6 more
doaj   +1 more source

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity

Biomolecules, 2022
The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J. Degroat, Yuxiang Sun, Troy A. Roepke   +9 more
doaj   +1 more source

Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons

Endocrine Connections, 2022
The nutritional environment during development periods induces metabolic programming, leading to metabolic disorders and detrimental influences on hum an reproductive health.
Shiori Minabe, Kinuyo Iwata, Youki Watanabe, Hirotaka Ishii, Hitoshi Ozawa   +4 more
doaj   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

Frontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama, Hitomi Tsuchida, Mayuko Nagae, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +1 more source