Results 11 to 20 of about 402 (139)

Population bursts in a modular neural network as a mechanism for synchronized activity in KNDy neurons. [PDF]

PLoS Computational Biology
The pulsatile activity of gonadotropin-releasing hormone neurons (GnRH neurons) is a key factor in the regulation of reproductive hormones. This pulsatility is orchestrated by a network of neurons that release the neurotransmitters kisspeptin, neurokinin
Wilfredo Blanco, Joel Tabak, Richard Bertram   +2 more
doaj   +11 more sources

Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation [PDF]

Current Opinion in Endocrine and Metabolic Research, 2022
The pulsatile release of gonadotropin-releasing hormone (GnRH) and its frequency are crucial for healthy reproductive function. To understand what drives GnRH pulses, a combination of experimental and mathematical modelling approaches has been used.
Zoe Plain, Margaritis Voliotis, Craig A. McArdle, Krasimira Tsaneva-Atanasova   +3 more
core   +7 more sources

Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility [PDF]

Metabolism, 2022
Abstract Kiss1 neurons in the hypothalamic arcuate-nucleus (ARC) play key roles in the control of GnRH pulsatility and fertility. A fraction of ARC Kiss1 neurons, termed KNDy, co-express neurokinin B (NKB; encoded by Tac2 ). Yet, NKB- and Kiss1-only neurons are also found in the ARC,
Inmaculada Velasco, Delphine Franssen, Silvia Daza-Dueñas, Katalin Skrapits, Szabolcs Takács, Encarnación Torres, Elvira Rodríguez-Vazquez, Miguel Ruiz-Cruz, Silvia León, Krisztina Kukoricza, Fu-Ping Zhang, Suvi Ruohonen, Diego Luque-Cordoba, Feliciano Priego-Capote, Francisco Gaytan, Francisco Ruiz-Pino, Erik Hrabovszky, Matti Poutanen, María J. Vázquez, Manuel Tena-Sempere   +19 more
core   +8 more sources

Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons [PDF]

Endocrine Connections, 2023
The nutritional environment during development periods induces metabolic programming, leading to metabolic disorders and detrimental influences on human reproductive health. This study aimed to determine the long-term adverse effect of intrauterine malnutrition on the reproductive center kisspeptin-neurokinin B-dynorphin A (KNDy ...
Shiori Minabe, Kinuyo Iwata, Youki Watanabe, Hirotaka Ishii, Hitoshi Ozawa   +4 more
core   +11 more sources

KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep

Endocrinology
Abstract KNDy neurons, located in the hypothalamic arcuate nucleus, coexpress kisspeptin (Kiss), neurokinin B, and dynorphin and play a crucial role in regulating GnRH/LH secretion in midgestation sheep fetuses. We hypothesize that KNDy-GnRH signaling is established during midgestation, with negative feedback acting through KNDy neurons ...
Rebecka Amodei, Sonnet S Jonker, Evelyn Lazen, Casey C Nestor, Charles T Estill, Charles E Roselli   +5 more
openaire   +3 more sources

KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS [PDF]

Reproduction, 2017
Abstract In the ewe, steroid hormones act on the hypothalamic arcuate nucleus (ARC) to initiate the GnRH/LH surge. Within the ARC, steroid signal transduction may be mediated by estrogen receptive dopamine-, β-endorphin- or neuropeptide Y (NPY)-expressing cells, as well as those co-localising kisspeptin, neurokinin B (NKB) and ...
Fergani, C, Routly, JE, Jones, DN, Pickavance, LC, Smith, RF, Dobson, H   +5 more
openaire   +4 more sources

Neurokinin B and reproductive functions: “KNDy neuron” model in mammals and the emerging story in fish [PDF]

General and Comparative Endocrinology, 2014
In mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH). Its regulatory actions are mediated by a subpopulation of kisspeptin neurons within the arcuate nucleus with co-expression of NKB and dynorphin A (commonly called the "KNDy neurons"). By
He, M, Lin, C, Hu, G, Wong, AOL
openaire   +5 more sources

Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2016
AbstractContext:A subpopulation of hypothalamic neurons colocalize three neuropeptides, namely kisspeptin, neurokinin B (NKB), and dynorphin, collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis); kisspeptin stimulates, NKB modulates, and dynorphin (an opioid) inhibits.Objective:To ...
Narayanaswamy, S, Prague, J, Jayasena, C, Papadopoulou, D, Mizamtsidi, M, Shah, A, Bassett, P, COMNINOS, A, Abbara, A, Bloom, S, Veldhuis, J, Dhillo, WS   +11 more
openaire   +5 more sources

The role of KNDy neurons in human reproductive health

Endocrine Journal
In the early 2000s, metastin, an endogenous ligand for G protein-coupled receptor 54 (GPR54), was discovered in human placental extracts. In 2003, GPR54 receptor mutations were found in a family with congenital hypogonadotropic hypogonadism. Metastin was
Aki Oride, Haruhiko Kanasaki
doaj   +3 more sources

Examining a central mechanism whereby undernutrition inhibits GnRH secretion via KNDy neurons

The Journal of Reproduction and Development
The negative impact of undernutrition on reproduction is evident in animal agriculture and human health, but our understanding of the central mechanism that links energy balance and reproduction is far from complete.
Casey C NESTOR, Arion KENNEDY
doaj   +3 more sources