GnRH pulse generator activity in mouse models of polycystic ovary syndrome [PDF]
eLifeOne in ten women in their reproductive age suffer from polycystic ovary syndrome (PCOS) that, alongside subfertility and hyperandrogenism, typically presents with increased luteinizing hormone (LH) pulsatility.
Ziyue Zhou +7 more
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Brainstem noradrenergic modulation of the kisspeptin neuron GnRH pulse generator in mice [PDF]
Nature CommunicationsBrainstem noradrenaline (NA) neurons modulate the activity of many neural networks including those responsible for the control of fertility. Using brain slice electrophysiology, we demonstrate that the arcuate nucleus kisspeptin (ARNKISS) neurons ...
Szilvia Vas +5 more
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Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats [PDF]
The Journal of Reproduction and Development, 2023 Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse ...
Takashi YAMAMURA +2 more
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Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice [PDF]
Nature Communications, 2022 Estrogen secreted by the ovary controls how the brain drives pulsatile reproductive hormone secretion. The authors show that in mice, estrogen receptor alpha within a specific population of hypothalamic kisspeptin neurons is the principal pathway through
H. James McQuillan +8 more
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Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats [PDF]
The Journal of Reproduction and Development, 2021 Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic gonadotropin-releasing hormone (GnRH) pulse generator.
Yoshihiro WAKABAYASHI +2 more
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Neuroendocrine mechanisms leading to novel control techniques of reproduction in livestock: Regulation of the GnRH pulse generator activity [PDF]
The Journal of Reproduction and DevelopmentPulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for normal reproductive function in mammals. GnRH pulses from the hypothalamus drive pulsatile gonadotropin release from the anterior pituitary, thereby
Satoshi OHKURA, Sho NAKAMURA
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Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction [PDF]
Frontiers in Endocrinology, 2021 Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama +4 more
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Examining a central mechanism whereby undernutrition inhibits GnRH secretion via KNDy neurons [PDF]
The Journal of Reproduction and DevelopmentThe negative impact of undernutrition on reproduction is evident in animal agriculture and human health, but our understanding of the central mechanism that links energy balance and reproduction is far from complete.
Casey C NESTOR, Arion KENNEDY
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Involvement of cocaine- and amphetamine-regulated transcript neurons in glucoprivic suppression of pulsatile luteinizing hormone secretion in female rats [PDF]
The Journal of Reproduction and DevelopmentMalnutrition often suppresses reproductive function by inhibiting the pulsatile secretion of gonadotropin-releasing hormone (GnRH)/gonadotropins in mammals.
Sena MATSUZAKI +11 more
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The role of amygdala GABA neurons in controlling stress and reproduction in female mice [PDF]
Nature CommunicationsStress can disrupt menstrual cycles, impair fertility and cause reproductive disfunction. The posterodorsal medial amygdala (MePD) integrates stress signals and regulates the gonadotropin-releasing hormone (GnRH) pulse generator through a dense network ...
Junru Yu +12 more
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