Results 21 to 30 of about 829,091 (166)

GnRH pulse generator frequency is modulated by kisspeptin and GABA-glutamate interactions in the posterodorsal medial amygdala in female mice. [PDF]

J Neuroendocrinol, 2022
Kisspeptin neurons in the arcuate nucleus of the hypothalamus generate GnRH pulses, and act as critical initiators of functional gonadotrophin secretion, and reproductive competency.
Lass G, Li XF, Voliotis M, Wall E, de Burgh RA, Ivanova D, McIntyre C, Lin XH, Colledge WH, Lightman SL, Tsaneva-Atanasova K, O'Byrne KT.   +11 more
europepmc   +4 more sources

Comparative Analysis of GnRH Pulse Generator Activity in Intact and Gonadectomized Male and Female Mice. [PDF]

Endocrinology
A subpopulation of kisspeptin neurons in the arcuate nucleus (ARN) of the hypothalamus functions as the GnRH pulse generator, driving the pulsatile secretion of LH from the anterior pituitary.
Chang B, Wall EG, Herbison AE, Han SY.
europepmc   +7 more sources

Role of Posterodorsal Medial Amygdala Urocortin-3 in Pubertal Timing in Female Mice

Frontiers in Endocrinology, 2022
Post-traumatic stress disorder impedes pubertal development and disrupts pulsatile LH secretion in humans and rodents. The posterodorsal sub-nucleus of the medial amygdala (MePD) is an upstream modulator of the hypothalamic gonadotropin-releasing hormone
Deyana Ivanova, XiaoFeng Li, Yali Liu, Caitlin McIntyre, Cathy Fernandes, Cathy Fernandes, Geffen Lass, Lingsi Kong, Kevin T. O’Byrne   +8 more
doaj   +1 more source

FRI419 Progesterone Regulation Of The GnRH Pulse Generator [PDF]

J Endocr Soc, 2023
Abstract Disclosure: E.G. Wall: None. A group of kisspeptin neurons located in the arcuate nucleus (ARN) of the hypothalamus represent the GnRH pulse generator and their activity is thought to be controlled primarily by the feedback actions of estradiol and progesterone (P4).
europepmc   +2 more sources

Modulation of pulsatile GnRH dynamics across the ovarian cycle via changes in the network excitability and basal activity of the arcuate kisspeptin network

eLife, 2021
Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH release.
Margaritis Voliotis, Xiao Feng Li, Ross Alexander De Burgh, Geffen Lass, Deyana Ivanova, Caitlin McIntyre, Kevin O'Byrne, Krasimira Tsaneva-Atanasova   +7 more
doaj   +1 more source

Dynamics of pulsatile activities of arcuate kisspeptin neurons in aging female mice

eLife, 2023
Reproductive senescence is broadly observed across mammalian females, including humans, eventually leading to a loss of fertility. The pulsatile secretion of gonadotropin-releasing hormone (GnRH), which is essential for gonad function, is primarily ...
Teppei Goto, Mitsue Hagihara, Kazunari Miyamichi   +2 more
doaj   +1 more source

Mathematical Modeling of the GnRH Pulse and Surge Generator [PDF]

SIAM Journal on Applied Dynamical Systems, 2007
We propose a mathematical model allowing for the alternating pulse and surge pattern of GnRH (Gonadotropin Releasing Hormone) secretion. The model is based on the coupling between two systems running on different time scales. The faster system corresponds to the average activity of GnRH neurons, while the slower one corresponds to the average activity ...
Clément, Frédérique, Françoise, Jean-Pierre   +1 more
openaire   +3 more sources

Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide. [PDF]

J Neuroendocrinol
Abstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
DeFazio RA, Burgess CR, Burger LL, Gibson AG, Moenter SM.   +4 more
europepmc   +2 more sources

Electrophysiological approach to the hypothalamic GnRH pulse generator [PDF]

Bioscientifica Proceedings, 2019
The hypothalamic GnRH pulse generator that regulates intermittent GnRH discharge into the pituitary portal circulation and thereby modulates pulsatile secretion of LH has been recognized as a key determinant of the reproductive function in mammals. Thus, various internal, as well as external, factors first modify the electrical activity of the GnRH ...
Y, Mori, T, Tanaka
openaire   +2 more sources

Divergent effects of hyperandrogenemia on the female reproductive neuroendocrine axis under different physiological conditions. [PDF]

J Neuroendocrinol
Abstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Rose L, Kauffman AS.
europepmc   +2 more sources