Results 41 to 50 of about 829,091 (166)
AIMS Medical Science, 2016 The pulsatile secretion of hormones is an efficient way of coding a large variety of chemical messages. The GnRH pulse pattern determines which gonadotropin is released when and at what concentration, prescribing a detailed set of instructions to the gonads that produce changes in the steroid hormone milieu.
Pasha Grachev, Robert L. Goodman
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F1000Research, 2020 This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj +1 more source
Optical control of the hypothalamic arcuate nucleus kisspeptin neuronal network with a photoswitchable peptide that drives luteinizing hormone release in female mice. [PDF]
J NeuroendocrinolAbstract Pulsatile gonadotropin‐releasing hormone (GnRH) and luteinizing hormone (LH) secretion are essential for reproductive function and are thought to be governed by arcuate nucleus kisspeptin Kiss1ARH neurons via neurokinin B (NKB) signaling through TacR3.
Qiu J +9 more
europepmc +2 more sources
Novel insights into the metabolic action of Kiss1 neurons
Endocrine Connections, 2020 Kiss1 neurons are essential regulators of the hypothalamic–pituitary–gonadal (HPG) axis by regulating gonadotropin-releasing hormone (GnRH) release. Compelling evidence suggests that Kiss1 neurons of the arcuate nucleus (Kiss1ARC), recently identified as
Rajae Talbi, Victor M Navarro
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Sustained induction of PMOS-like phenotype in mice exposed to letrozole in drinking water. [PDF]
J NeuroendocrinolAbstract Polyendocrine metabolic ovarian syndrome (PMOS; formerly polycystic ovary syndrome) is the most common endocrinopathy affecting women of reproductive age, characterized by ovarian dysfunction and hyperandrogenism, with metabolic disturbances including insulin resistance and obesity also present for 50% of PMOS patients.
Stevenson KA +3 more
europepmc +2 more sources
Frontiers in Endocrinology, 2023 IntroductionEstrogenic endocrine disrupting chemicals (EDCs) such as diethylstilbestrol (DES) are known to alter the timing of puberty onset and reproductive function in females.
Delphine Franssen +9 more
doaj +1 more source
[Electrophysiological studies on the hypothalamic GnRH pulse generator].
Nihon Naibunpi Gakkai zasshi, 1992 Gonadal function in mammals depends on gonadotropins secreted from the pituitary gland in a pulsatile manner. This pulsatility is governed by the periodic activation of the hypothalamic GnRH pulse generator. By means of multiple unit activity (MUA) recording techniques, characteristics increases in the neuronal activity, each of which is associated ...
M, Nishihara, H, Hiruma, Y, Mori
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Induction of Gonadotropins for Reproductive Control
Journal of Dentistry Indonesia, 2015 Much of the recent research on gonadotropin – related control processes of reproduction and reproductive maturation has concentrated on the neuronal and molecular biology of gonadotropin release.
Elza Ibrahim Auerkari
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Frontiers in Endocrinology, 2022 Kisspeptin neurons are mainly located in the arcuate (Kiss1ARC, vis-à-vis the GnRH pulse generator) and anteroventral periventricular nucleus (Kiss1AVPV, vis-à-vis the GnRH surge generator).
Xi Shen +8 more
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Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation [PDF]
, 2022 The pulsatile release of gonadotropin-releasing hormone (GnRH) and its frequency are crucial for healthy reproductive function. To understand what drives GnRH pulses a combination of experimental and mathematical modelling approaches have been used ...
K Tsaneva-Atanasova (21846731) +3 more
core +2 more sources