A population of kisspeptin/neurokinin B neurons in the arcuate nucleus may be the central target of the male effect phenomenon in goats. [PDF]
PLoS ONE, 2013 Exposure of females to a male pheromone accelerates pulsatile gonadotropin-releasing hormone (GnRH) secretion in goats. Recent evidence has suggested that neurons in the arcuate nucleus (ARC) containing kisspeptin and neurokinin B (NKB) play a pivotal ...
Kohei Sakamoto +6 more
doaj +1 more source
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
eLife, 2021 The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out
Xinhuai Liu +7 more
doaj +1 more source
The Journal of Reproduction and Development, 2020 Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI +14 more
doaj +1 more source
Kisspeptin Is a Component of the Pulse Generator for GnRH Secretion in Female Sheep But Not THE Pulse Generator [PDF]
Endocrinology, 2015 We tested the hypothesis that kisspeptin cells constitute the “pulse generator” for GnRH secretion. In ewes, we determined whether iv administered kisspeptin elicits a secretory pulse of LH in anaesthetized, sex-steroid suppressed ovariectomized ewes.
Ahmed, Ezzat +2 more
openaire +2 more sources
Ethanolamine plasmalogens increase luteinising hormone pulsatility and are associated with GPR61 expression in bovine gonadotrophin-releasing hormone neurons. [PDF]
J NeuroendocrinolEthanolamine plasmalogens increased LH pulse frequency. GPR61 was expressed in GnRH neurons and gonadotrophs, suggesting a role in neuroendocrine regulation. Ethanolamine plasmalogens (EPls), but not choline plasmalogens (CPls), may act via GPR61 expressed in GnRH neurons in the preoptic area and in anterior pituitary gonadotrophs.
Kadokawa H +4 more
europepmc +2 more sources
Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]
, 2012 Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques +13 more
core +1 more source
A Fully Differential Digital CMOS Pulse UWB Generator [PDF]
, 2009 A new fully-digital CMOS pulse generator for impulse-radio Ultra-Wide-Band (UWB) systems is presented. First, the shape of the pulse which best fits the FCC regulation in the 3.1-5 GHz sub-band of the entire 3.1-10.6 GHz UWB bandwidth is derived and ...
Graziano, Mariagrazia +2 more
core +1 more source
Kisspeptin-neuron control of LH pulsatility and ovulation
Frontiers in Endocrinology, 2022 Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads
Harvey Stevenson +11 more
doaj +1 more source
Integrating Models to Decode the GnRH Pulse Generator
Abstract The gonadotrophin-releasing hormone (GnRH) pulse generator is a critical neural oscillator that governs reproductive function through the pulsatile release of luteinising hormone (LH) and follicle stimulating hormone (FSH).
Nechyporenko K +5 more
europepmc +2 more sources