Results 11 to 20 of about 829,091 (166)
The Origin of GnRH Pulse Generation: An Integrative Mathematical-Experimental Approach [PDF]
The Journal of Neuroscience, 2019 Fertility critically depends on the gonadotropin-releasing hormone (GnRH) pulse generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoinin-B and dynorphin. Here, using mathematical modeling and in vivo optogenetics we reveal for the first time how ...
Margaritis Voliotis +6 more
core +13 more sources
In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2022 A hypothalamic pulse generator located in the arcuate nucleus controls episodic release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) and is essential for reproduction.
Aleisha Moore +2 more
exaly +3 more sources
Definition of the hypothalamic GnRH pulse generator in mice [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Neural networks located in the hypothalamus are responsible for generating ultradian patterns of hormone secretion that control a wide variety of functions. How these neural networks generate pulsatile hormone secretion remains unknown.
Richard Piet, Jenny Clarkson, Joon S Kim
exaly +5 more sources
Direct evidence that KNDy neurons maintain gonadotropin pulses and folliculogenesis as the GnRH pulse generator [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Reports suggest that at least 25% of women suffering from reproductive disorders are due to hypothalamic dysfunction. Pulsatile gonadotropin-releasing hormone (GnRH) regimens are used for infertile women.
Naoko Inoue +2 more
exaly +5 more sources
Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. [PDF]
PLoS ONE, 2009 BACKGROUND:Kisspeptin and its G protein-coupled receptor (GPR) 54 are essential for activation of the hypothalamo-pituitary-gonadal axis. In the rat, the kisspeptin neurons critical for gonadotropin secretion are located in the hypothalamic arcuate (ARC)
Xiao-Feng Li +10 more
doaj +3 more sources
The neurochemistry of the GnRH pulse generator
Acta Neurobiologiae Experimentalis, 1996 We review the crucial role of the two neurotransmitters norepinephrine (NE) and GABA in eliciting GnRH pulses. NE acts via an alpha1-receptor mechanism and also GABA acts at the alpha-subtype of the GABA receptor. The function of NE appears to be induction of phasic activation of GnRH neurons and GABA inhibits GnRH neurons tonically until they are all ...
Wuttke, W. +6 more
core +5 more sources
GnRH Pulse Generator Activity Across the Estrous Cycle of Female Mice [PDF]
Endocrinology, 2019 A subpopulation of kisspeptin neurons located in the arcuate nucleus (ARN) operate as the GnRH pulse generator. The activity of this population of neurons can be monitored in real-time for long periods using kisspeptin neuron-selective GCaMP6 fiber photometry.
H James McQuillan +3 more
openaire +3 more sources
Progesterone Regulation of the GnRH Pulse Generator
Kisspeptin neurons in the arcuate nucleus (ARN) represent the gonadotrophin- releasing hormone (GnRH) pulse generator responsible for driving the pulsatile release of GnRH and luteinising hormone (LH) secretion. In a healthy menstruating woman, following the mid-cycle ovulation, progesterone (P4) levels dramatically increase and exert a negative ...
openaire +4 more sources
KNDy neurons as the GnRH pulse generator: Recent studies in ruminants. [PDF]
Peptides, 2023 This review considers three aspects of recent work on the role of KNDy neurons in GnRH pulse generation in ruminants. First, work on basic mechanisms of pulse generation includes several tests of this hypothesis, all of which support it, and evidence that Kiss1r-containing neurons form a positive feedback circuit with the KNDy neural network that ...
Nestor CC +4 more
europepmc +3 more sources
New methods to investigate the GnRH pulse generator. [PDF]
J Mol Endocrinol, 2023 The exact neural construct underlying the dynamic secretion of gonadotrophin-releasing hormone (GnRH) has only recently been identified despite the detection of multiunit electrical activity volleys associated with pulsatile luteinising hormone (LH) secretion four decades ago.
Ivanova D, O'Byrne KT.
europepmc +3 more sources