Results 51 to 60 of about 829,091 (166)

Circulating levels and the bioactivity of miR-30b increase during pubertal progression in boys

Frontiers in Endocrinology, 2023
BackgroundPuberty marks the transition from childhood to adulthood and is initiated by activation of a pulsatile GnRH secretion from the hypothalamus.
Nina Mørup, Nina Mørup, Rytis Stakaitis, Rytis Stakaitis, Rytis Stakaitis, Ailsa Maria Main, Ailsa Maria Main, Ailsa Maria Main, Ieva Golubickaite, Ieva Golubickaite, Ieva Golubickaite, Casper P. Hagen, Casper P. Hagen, Anders Juul, Anders Juul, Anders Juul, Kristian Almstrup, Kristian Almstrup, Kristian Almstrup   +18 more
doaj   +1 more source

The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 1; peer review: 4 approved]

F1000Research, 2019
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj   +1 more source

Dynamic Hormone Control of Stress and Fertility

Frontiers in Physiology, 2020
Neuroendocrine axes display a remarkable diversity of dynamic signaling processes relaying information between the brain, endocrine glands, and peripheral target tissues.
Eder Zavala, Eder Zavala, Margaritis Voliotis, Tanja Zerenner, Joël Tabak, Jamie J. Walker, Jamie J. Walker, Xiao Feng Li, John R. Terry, John R. Terry, Stafford L. Lightman, Kevin O'Byrne, Krasimira Tsaneva-Atanasova, Krasimira Tsaneva-Atanasova   +13 more
doaj   +1 more source

Central Mechanism Controlling Pubertal Onset in Mammals: A Triggering Role of Kisspeptin

Frontiers in Endocrinology, 2019
Pubertal onset is thought to be timed by an increase in pulsatile gonadotropin-releasing hormone (GnRH)/gonadotropin secretion in mammals. The underlying mechanism of pubertal onset in mammals is still an open question.
Yoshihisa Uenoyama, Naoko Inoue, Sho Nakamura, Hiroko Tsukamura   +3 more
doaj   +1 more source

Kisspeptin Neurons in the Infundibular Nucleus of Ovariectomized Cats and Dogs Exhibit Unique Anatomical and Neurochemical Characteristics

Frontiers in Neuroscience, 2020
Neurons co-synthesizing kisspeptin (KP), neurokinin B (NKB), and dynorphin (“KNDy neurons”) in the hypothalamic arcuate/infundibular nucleus (INF) form a crucial component of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) “pulse ...
Éva Rumpler, Szabolcs Takács, Balázs Göcz, Ferenc Baska, Ottó Szenci, Ottó Szenci, András Horváth, Philippe Ciofi, Erik Hrabovszky, Katalin Skrapits   +9 more
doaj   +1 more source

Acute progesterone feedback on gonadotropin secretion is not demonstrably altered in estradiol‐pretreated women with polycystic ovary syndrome

Physiological Reports, 2022
Women with polycystic ovary syndrome (PCOS) demonstrate gonadotropin‐releasing hormone (GnRH) pulse generator resistance to suppression with 7 days of progesterone and estradiol administration.
Su Hee Kim, Jessica A. Lundgren, James T. Patrie, Christine M. Burt Solorzano, Christopher R. McCartney   +4 more
doaj   +1 more source

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach

Frontiers in Endocrinology, 2019
The mechanisms underlying the initiation of puberty, one of the cornerstones of human evolution, have not been fully elucidated as yet. However, recently, an accumulating body of evidence has helped unravel several critical aspects of the process.
Sarantis Livadas, George P. Chrousos
doaj   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

TRPM8 and TRPM2 ion channels determine sex differences in thermal preference in mice

The Journal of Physiology, EarlyView.
Abstract figure legend Too hot or too cold? How do we know? Animals seek a ‘comfort temperature’ in between ‘too hot’ (far left) and ‘too cold’ (far right). In mammals and birds, females (left) prefer warmer temperatures than males (right). We show here that in mice, the comfort temperature is determined by a balance of sensory input (black arrows ...
Bruno Vilar, Peter A. McNaughton
wiley   +1 more source