Results 71 to 80 of about 829,091 (166)

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Activated Clotting Time‐Guided Systemic Heparinization as One Component of a Stepwise Salvage Algorithm for Inadequate Internal Mammary Artery Flow in Microsurgical Breast Reconstruction

Microsurgery, Volume 46, Issue 7, October 2026.
ABSTRACT Background The internal mammary vessels are commonly used as recipient vessels for free flap breast reconstruction. However, inadequate arterial flow may be encountered intraoperatively. This hypothesis‐generating study evaluated the safety and feasibility of activated clotting time (ACT)‐guided systemic heparinization as one component of a ...
Kazuhiro Tsunekawa, Daisuke Yanagisawa, Shunsuke Yuzuriha   +2 more
wiley   +1 more source

Timing feedback-inhibition of the male reproductive hormone axis [PDF]

, 2008
Hormonal methods of male contraception have addressed feedback-inhbition of the cascade of hormones that has evolved to regulate sperm production but high concentrations of testosterone (T) in the blood have not worked satisfactorily.
Gopal Gupta, Shailesh S. Tondwal, Ritu R. Malik, K Subramanian Venkatesh, Amit Misra, Shailesh Tondwal, Ritu Malik   +6 more
core   +1 more source

Neuronal network dynamics in the posterodorsal amygdala: shaping reproductive hormone pulsatility [PDF]

Normal reproductive function and fertility rely on the rhythmic secretion of gonadotropin-releasing hormone (GnRH), which is driven by the hypothalamic GnRH pulse generator.
O’Byrne, Kevin T., Li, Xiao Feng, Walker, Jamie J., Tsaneva-Atanasova, Krasimira, Ivanova, Deyana, Hollings, Owen, Nechyporenko, Kateryna, Voliotis, Margaritis, O'Byrne, Kevin T, Walker, Jamie J   +9 more
core   +5 more sources

Functional interactions between anteroventral periventricular kisspeptin neurons and gonadotropin‐releasing hormone neurons in female mice

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Kisspeptin neurons in the rostral hypothalamus are hypothesized to initiate preovulatory gonadotropin‐releasing hormone (GnRH) surges by causing estradiol‐dependent activation of GnRH neuron action potential firing and subsequent GnRH release.
J. Rudolph Starrett, Xi Chen, Devon Krasner, Chrystian D. Phillips, Suzanne M. Moenter   +4 more
wiley   +1 more source

Suppression of the GnRH pulse generator by Neurokinin B involves a k-opioid receptor-dependent mechanism [PDF]

, 2012
Neurokinin B (NKB) and its receptor (NK3R) are coexpressed with kisspeptin, Dynorphin A (Dyn), and their receptors [G-protein-coupled receptor-54 (GPR54)] and -opioid receptor (KOR), respectively] within kisspeptin/NKB/Dyn (KNDy) neurons in the ...
Grachev, P, Kinsey-Jones, J. S., Grachev, Pasha, di Domenico, A L, Millar, R P, Li, X. F., Li, X.F., Grachev, P., O'Byrne, K T, Lightman, S. L., Millar, Robert P., Lightman, S L, O'Byrne, K. T., Lightman, Stafford L., Li, X F, O'Byrne, Kevin T., Millar, R. P., di Domenico, A. L., Kinsey-Jones, J S, Kinsey-Jones, J.S., Di Domenico, A.L.   +20 more
core   +1 more source

How to pause fertility

eLife
Prolactin suppresses the ovarian cycles of lactating mice by directly repressing the activity of a cell population known as kisspeptin neurons.
Aleisha M Moore
doaj   +1 more source

Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region.

PLoS ONE, 2013
Neurons synthesizing neurokinin B (NKB) and kisspeptin (KP) in the hypothalamic arcuate nucleus represent important upstream regulators of pulsatile gonadotropin-releasing hormone (GnRH) neurosecretion.
Erik Hrabovszky, Beáta Á Borsay, Kálmán Rácz, László Herczeg, Philippe Ciofi, Stephen R Bloom, Mohammad A Ghatei, Waljit S Dhillo, Zsolt Liposits   +8 more
doaj   +1 more source

The role of GABAergic signalling in stress-induced suppression of GnRH pulse generator frequency in female rats

, 2012
Stress exerts profound inhibitory effects on reproductive function by suppressing the pulsatile release of gonadotrophin-releasing hormone (GnRH), and therefore luteinising hormone (LH).
O'Byrne, KT, Shao, B., Jeyaram, A, Li, X. F., Lin, Y. S., Lightman, S. L., Goundry, AL, Shao, B, Hu, M. H., Lightman, SL, Goundry, A. L. R., O'Byrne, Kevin, Li, XF, Lin, YS, Jeyaram, A., Hu, MH   +15 more
core   +1 more source

Beyond canonical homeostasis: Dynamic, plastic, and intermittently unregulated physiology as the norm

Physiological Reports, Volume 14, Issue 20, October 2026.
Abstract Homeostasis is often taught as steady‐state regulation keeping internal variables within narrow limits—reflecting a mammalian bias. Yet, canonical homeostasis is far from universal. In many animals, including humans, normal physiological states allow some variables to fluctuate cyclically or stochastically while others remain tightly ...
Warren Burggren, Tobis Wang
wiley   +1 more source