Results 91 to 100 of about 829,091 (166)

At the transition from invertebrates to vertebrates a novel GnRH-like peptide emerges in amphioxus [PDF]

, 2014
This work was supported by a grant from the Canadian Natural Sciences and Engineering Council (NSERC).Gonadotropin-releasing hormone (GnRH) is a critical reproductive regulator in vertebrates.
Roch, Graeme, Sherwood, Nancy, Tello, Javier, Tello, Javier; id_orcid   +3 more
core   +1 more source

Polycystic ovary syndrome and impact on health

Middle East Fertility Society Journal, 2011
Polycystic ovary syndrome (PCOS) is a multifactorial, heterogeneous, complex genetic, endocrine and metabolic disorder, diagnostically characterized by chronic anovulation, polycystic ovaries and biochemical and clinical manifestations of ...
Gautam N. Allahbadia, Rubina Merchant
doaj   +1 more source

Studies of the GnRH pulse generator. Developmental and location-specific regulation of GnRH secretion [PDF]

, 2017
The hypothalamo-pituitary-gonadal (HPG) axis governs reproductive function. Gonadotropin-releasing hormone (GnRH) neurons play a critical role in the central regulation of the HPG axis through the episodic release of the GnRH peptide to the hypophyseal blood.
openaire   +1 more source

Supplementary Material for: The Effects of Chronic Subcutaneous Administration of an Investigational Kisspeptin Analog, TAK-683, on Gonadotropin-Releasing Hormone Pulse Generator Activity in Goats

, 2017
The continuous activation of the kisspeptin receptor by its agonists causes the abrogation of kisspeptin signaling, leading to decreased pulsatile luteinizing hormone (LH) secretion. Employing this phenomenon as a tool for probing kisspeptin action, this
Tanaka T. (3272895), Matsui H. (4130476), Yamamura T. (4150090), Kusaka M. (4150087), Ohkura S. (4150084), Sakamoto K. (3596723), Wakabayashi Y. (4150081), Okamura H. (3643315)   +7 more
core   +1 more source

POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons

eLife
Inactivating mutations in the melanocortin 4 receptor (MC4R) gene cause monogenic obesity. Interestingly, female patients also display various degrees of reproductive disorders, in line with the subfertile phenotype of Mc4r KO female mice.
Rajae Talbi, Todd L Stincic, Kaitlin Ferrari, Choi Ji Hae, Karol Walec, Elizabeth Medve, Achi Gerutshang, Silvia Leon, Elizabeth A McCarthy, Oline K Rønnekleiv, Martin J Kelly, Victor M Navarro   +11 more
doaj   +1 more source

Characterization of GnRH Pulse Generator Activity in Male Mice Using GCaMP Fiber Photometry

, 2019
Kisspeptin neurons located in the hypothalamic arcuate nucleus are thought to represent the GnRH pulse generator responsible for driving pulsatile LH secretion.
Herbison, Allan E, Han, Su Young, Cheong, Isaiah, Kane, Grace, Han, Su Young; id_orcid   +4 more
core   +1 more source

The Inhibitory Effects of Neurokinin B on GnRH Pulse Generator Frequency in the Female Rat

, 2012
Neurokinin B (NKB) and its receptor (neurokinin-3 receptor) are coexpressed with kisspeptin and dynorphin A (Dyn) within neurons of the hypothalamic arcuate nucleus, the suggested site of the GnRH pulse generator.
James S. Kinsey-Jones, Grachev, P, O'Byrne, KT, Lin, Yuan Shao, Li, Xiao Feng, Grachev, Pasha, Milligan, SR, Pasha Grachev, Stafford L. Lightman, Xiao Feng Li, Kinsey-Jones, JS, Lightman, Stafford L., Lightman, SL, O'Byrne, Kevin, Li, XF, Yuan Shao Lin, Lin, YS, Stuart R. Milligan, Kinsey-Jones, James S., Kevin T. O'Byrne, Milligan, Stuart R.   +20 more
core   +1 more source

Two Subgroups of Gonadotropin Releasing Hormone Neurons Control Gonadotropin Secretion in Rats

, 1998
Two distinct subgroups of gonadotropin-releasing hormone (GnRH) neurons are involved in the control of luteinizing hormone secretion, at least in rats: one subgroup located in the mediobasal hypothalamus constitutes the GnRH pulse generator associated ...
Toshiya Funabashi, Fukuko Kimura
core   +1 more source

Precision Targeted Therapy for PCOS: Emerging Drugs, Translational Challenges, and Future Opportunities

Biomedicines
Polycystic Ovary Syndrome (PCOS) is characterized by a self-perpetuating vicious cycle between insulin resistance (IR) and hyperandrogenism (HA). While lifestyle management remains the internationally recommended first-line treatment, current clinical ...
Xinhong Wu, Wei Yi, Xiawen Liu
doaj   +1 more source

Chemogenetic activation of PVN CRH neurons disrupts the estrous cycle and LH dynamics in female mice

Frontiers in Endocrinology
IntroductionThe impact of stress on reproductive function is significant. Hypothalamic paraventricular nucleus (PVN) corticotrophin-releasing hormone (CRH) plays a major role in regulating the stress response. Understanding how the hypothalamic-pituitary-
Junru Yu, Xiao-Feng Li, Krasimira Tsaneva-Atanasova, Krasimira Tsaneva-Atanasova, Eder Zavala, Kevin T. O’Byrne   +5 more
doaj   +1 more source