Results 61 to 70 of about 829,091 (166)

Regulation of gonadotropins by corticotropin-releasing factor and urocortin

Frontiers in Endocrinology, 2013
While stress activates the hypothalamic-pituitary-adrenal (HPA) axis, it suppresses the hypothalamic-pituitary-gonadal (HPG) axis. Corticotropin-releasing factor (CRF) is a major regulatory peptide in the HPA axis during stress.
Kazunori eKageyama
doaj   +1 more source

Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
This meta‐analysis of 42 studies, including 5363 women with PCOS, found that obesity was associated with more severe reproductive, androgenic, metabolic, and cardiometabolic abnormalities. Lean PCOS also carried substantial metabolic risk, supporting phenotype‐informed assessment and cardiometabolic screening regardless of BMI.
Fatema Tuz Zahura Aalpona, Apurba Sarker, Lutfun Nahar, Md Abdul Bari Robel, A. B. M. Kamrul‐Hasan   +4 more
wiley   +1 more source

Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies

Scientific Reports
Dysfunction of central serotonergic neurons is known to cause depressive disorders in humans, who often show reproductive and/or glucose metabolism disorders.
Sho Nakamura, Takuya Sasaki, Yoshihisa Uenoyama, Naoko Inoue, Marina Nakanishi, Koki Yamada, Ai Morishima, Reika Suzumura, Yuri Kitagawa, Yasuhiro Morita, Satoshi Ohkura, Hiroko Tsukamura   +11 more
doaj   +1 more source

Ghrelin Decreases Firing Activity of Gonadotropin-Releasing Hormone (GnRH) Neurons in an Estrous Cycle and Endocannabinoid Signaling Dependent Manner. [PDF]

, 2013
The orexigenic peptide, ghrelin is known to influence function of GnRH neurons, however, the direct effects of the hormone upon these neurons have not been explored, yet.
Farkas, Imre, Liposits, Zsolt, Vastagh, Csaba, Sárvári, Miklós   +3 more
core  

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Impact of Reactive Temperament on Bull Fertility in Natural Service

Reproduction in Domestic Animals, Volume 61, Issue 11, November 2026.
ABSTRACT The study aimed to evaluate the influence of temperament on semen quality and fertility in Nelore bulls. Two groups were selected based on ethological analysis, consisting of animals with either calm temperament (CA, n = 8) or reactive temperament (RE, n = 8).
Larissa de Almeida Martin, Mariana Karla Francolino da Silva, Marcelo Sant’Ana Borges, Luana Gomes Fernandes, Richardt Gama Landgraf, Fábio Morato Monteiro, André Maciel Crespilho   +6 more
wiley   +1 more source

Estrogen Receptor Beta Isoforms Interplay Integrates Nuclear and Extra‐Nuclear Signaling to Modulate Human Granulosa Cell Growth

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Working model of ERβ isoform signaling in human granulosa cells. Upon E2 binding, ERβ1 activates ERE‐dependent transcription and represses AP‐1 activity through Jun/Fos interactions. In contrast, ERβ2, ERβ4, and ERβ5 lack E2 binding and ERE activity but promote AP‐1‐dependent transcription and counteract ERβ1 repression, including after phosphorylation
Clémentine Marie, Inza‐Noor Baskaran, Raphaël Corre, Anne Mayeur, Michaël Grynberg, Guillaume Chevreux, David L'Hôte, Joëlle Cohen‐Tannoudji, Stéphanie Chauvin   +8 more
wiley   +1 more source

Systems Pharmacology and Multitarget Modulation of Letrozole–HFD‐Induced Polycystic Ovarian Syndrome by Fruit Pulp of Prunus armeniaca

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
Integrated systems pharmacology and in vivo evaluation reveal that hydroalcoholic extract of fruit pulp of Prunus armeniaca (HAE of FPPA) ameliorates letrozole–HFD‐induced PCOS through multitarget modulation. Network analysis identifies 105 shared targets enriched in PI3K/Akt, MAPK, HIF‐1, and inflammatory pathways, while treatment improves hormonal ...
Ratna Priya, Nitish Singh Jangwan, Swati Dobhal, Shradha Bisht, Mamta F. Singh   +4 more
wiley   +1 more source

Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling [PDF]

, 2019
Context: Kisspeptin-Neurokinin B-Dynorphin neurons are critical regulators of the hypothalamic-pituitary-gonadal axis. Neurokinin B (NKB) and dynorphin are hypothesized to influence the frequency of gonadotropin-releasing hormone (GnRH) pulses; whereas ...
Stewart, SE, Navarro, VM, Hall, Janet E, Terasawa, E, Fergani, C, Cole, TR, Arlt, W, Lippincott, MF, Terasawa, Ei, Lippincott, Margaret F, Farooqi, I Sadaf, Navarro, Victor M, Chan, Y-M, Chan, Yee-ming, Shaw, ND, Talbi, R, Seminara, SB, Hall, JE, León, S, León, Silvia, Arlt, Wiebke, Jones, CM, Farooqi, IS, Fergani, Chrysanthi, Seminara, Stephanie Beth, Shaw, Natalie D, Cole, Trevor R, Jones, Christopher M, Stewart, Susan E, Talbi, Rajae   +29 more
core   +1 more source

Human biomarker navigator

iMeta, Volume 5, Issue 5, October 2026.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source