Results 21 to 30 of about 402 (139)

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +2 more sources

Role of KNDy neurons in puberty onset in male offspring following prenatal androgen exposure

Endocrine Connections
Objective: Emerging evidence links prenatal androgen excess to altered pubertal timing, yet the neuroendocrine mechanisms mediating this effect in male offspring remain poorly characterized.
Runfei Ge, Yun Zhang, Yongting Yuan, Tingting Li, GuiYu Qiu, Shuaijun Guo, Lianguo Fu   +6 more
doaj   +3 more sources

Hypothalamic KNDy neuron expression in streptozotocin-induced diabetic female rats [PDF]

Journal of Endocrinology, 2022
Kisspeptin neurons, i.e. KNDy neurons, in the arcuate nucleus (ARC) coexpress neurokinin B and dynorphin and regulate gonadotropin-releasing hormone/luteinizing hormone (LH) pulses. Because it remains unclear whether these neurons are associated with reproductive dysfunction in diabetic females, we examined the expression of KNDy neurons detected by ...
Hiroyuki Enomoto, Kinuyo Iwata, Keisuke Matsumoto, Mai Otsuka, Akio Morita, Hitoshi Ozawa   +5 more
openaire   +2 more sources

The Role of KNDy Neurons in Estrogen Modulation of LH Release, Body Weight, and Thermoregulation

, 2012
Up to 80% of menopausal women suffer from hot flushes, consisting of a coordinated activation of heat loss mechanisms (sweating, cutaneous vasodilatation, etc.).
Smith, Melinda Anne
core   +4 more sources

Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats

Scientific Reports, 2023
The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy) neurons and anteroventral periventricular nucleus (AVPV) kisspeptin neurons, respectively, in female rodents ...
Mayuko Nagae, Koki Yamada, Yuki Enomoto, Mari Kometani, Hitomi Tsuchida, Arvinda Panthee, Miku Nonogaki, Nao Matsunaga, Marina Takizawa, Sena Matsuzaki, Masumi Hirabayashi, Naoko Inoue, Hiroko Tsukamura, Yoshihisa Uenoyama   +13 more
doaj   +1 more source

GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. [PDF]

PLoS ONE, 2012
Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets.
Pasha Grachev, Xiao Feng Li, Yuan Shao Lin, Ming Han Hu, Leena Elsamani, Stewart J Paterson, Robert P Millar, Stafford L Lightman, Kevin T O'Byrne   +8 more
doaj   +1 more source

Synergistic Control of KNDy Neuronal Influence on Energy Balance by Ghrelin and Estradiol [PDF]

Journal of the Endocrine Society, 2021
Abstract The gut peptide, ghrelin, mediates negative energy homeostasis and the neuroendocrine control of energy homeostasis by acting through its receptor, growth hormone secretagogue receptor (GHSR). GHSR, expressed in hypothalamic Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons in the arcuate (ARC), is well known to regulate energy ...
Conde, Kristie M, Kulyk, Danielle, Roepke, Troy Adam   +2 more
openaire   +1 more source

The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction

Frontiers in Endocrinology, 2022
The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction.
Qinying Xie, Yafei Kang, Chenlu Zhang, Ye Xie, Chuxiong Wang, Jiang Liu, Caiqian Yu, Hu Zhao, Donghui Huang   +8 more
doaj   +1 more source

SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]

BAG. Journal of Basic and Applied Genetics, 2020
Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F., Castellote M.A., Corva P.M.   +2 more
doaj   +1 more source

Chronic Undernutrition Inhibits KNDy Neurons in Ovariectomized Ewe Lambs

Journal of the Endocrine Society, 2021
Abstract Undernutrition negatively impacts reproductive success, at least in part, through a central suppression of GnRH secretion. Given that GnRH neurons are devoid of receptors for peripheral metabolic hormones such as leptin and insulin, nutritional regulation of GnRH secretion must be through afferent input. Neurons which co-express
Harlow, KaLynn, Griesgraber, Max, Seman, Andrew, Shuping, Sydney, Sommer, Jeffrey, Hileman, Stanley, Nestor, Casey   +6 more
openaire   +1 more source