Results 1 to 10 of about 455,128 (153)

Population Bursts in a Modular Neural Network as a Mechanism for Synchronized Activity in KNDy Neurons [PDF]

PLoS Computational Biology
The pulsatile activity of gonadotropin-releasing hormone neurons (GnRH neurons) is a key factor in the regulation of reproductive hormones. This pulsatility is orchestrated by a network of neurons that release the neurotransmitters kisspeptin, neurokinin
Richard Bertram, Wilfredo Blanco Figuerola, Joël Tabak   +2 more
exaly   +14 more sources

Hyperandrogenism induces proportional changes in the expression of Kiss-1, Tac2, and DynA in hypothalamic KNDy neurons [PDF]

Reproductive Biology and Endocrinology, 2022
Background Kisspeptin released from Kiss-1 neurons in the hypothalamus plays an essential role in the control of the hypothalamic–pituitary–gonadal axis by regulating the release of gonadotropin-releasing hormone (GnRH).
Hiroe Okada, Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Zolzaya Tumurgan, Aki Oride, Satoru Kyo   +5 more
doaj   +5 more sources

Examining a central mechanism whereby undernutrition inhibits GnRH secretion via KNDy neurons [PDF]

The Journal of Reproduction and Development
The negative impact of undernutrition on reproduction is evident in animal agriculture and human health, but our understanding of the central mechanism that links energy balance and reproduction is far from complete.
Casey C NESTOR, Arion KENNEDY
doaj   +4 more sources

The Role of KNDy Neurons in Human Reproductive Health

Endocrine Journal
In the early 2000s, metastin, an endogenous ligand for G protein-coupled receptor 54 (GPR54), was discovered in human placental extracts. In 2003, GPR54 receptor mutations were found in a family with congenital hypogonadotropic hypogonadism. Metastin was
Aki Oride, Haruhiko Kanasaki
exaly   +5 more sources

Role of KNDy neurons in puberty onset in male offspring following prenatal androgen exposure [PDF]

Endocrine Connections
Objective: Emerging evidence links prenatal androgen excess to altered pubertal timing, yet the neuroendocrine mechanisms mediating this effect in male offspring remain poorly characterized.
Runfei Ge, Yun Zhang, Yongting Yuan, Tingting Li, GuiYu Qiu, Shuaijun Guo, Lianguo Fu   +6 more
doaj   +4 more sources

Direct Evidence That KNDy Neurons Maintain Gonadotropin Pulses and Folliculogenesis as the GnRH Pulse Generator [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Reports suggest that at least 25% of women suffering from reproductive disorders are due to hypothalamic dysfunction. Pulsatile gonadotropin-releasing hormone (GnRH) regimens are used for infertile women.
Naoko Inoue, Makoto Sanbo, Hitomi Tsuchida   +2 more
exaly   +5 more sources

Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction [PDF]

Frontiers in Endocrinology, 2021
Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama, Mayuko Nagae, Hitomi Tsuchida, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +2 more sources

Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies [PDF]

Scientific Reports
Dysfunction of central serotonergic neurons is known to cause depressive disorders in humans, who often show reproductive and/or glucose metabolism disorders.
Sho Nakamura, Takuya Sasaki, Yoshihisa Uenoyama, Naoko Inoue, Marina Nakanishi, Koki Yamada, Ai Morishima, Reika Suzumura, Yuri Kitagawa, Yasuhiro Morita, Satoshi Ohkura, Hiroko Tsukamura   +11 more
doaj   +2 more sources

In vitro differentiation of the hypothalamic KNDy neuron, a master regulator for reproduction, from mouse embryonic stem cells [PDF]

Reproductive Biology and Endocrinology
Background Hypothalamic kisspeptin neurons are master regulators of reproduction in mammals, including humans and rodents, via direct stimulation of gonadotropin-releasing hormone (GnRH) neurons.
Natsuki Miyake, Hidetaka Suga, Satoko Osuka, Tomomi Seki, Reina Sonehara, Ayako Muraoka, Tomoko Nakamura, Bayasula, Tsutomu Miwata, Mika Soen, Mayu Sakakibara, Shiori Go, Saki Hasegawa, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura, Hiroshi Arima, Hiroaki Kajiyama   +17 more
doaj   +2 more sources

Effects of chrysin on Kisspeptin, neurokinin B, and dynorphin neurons and gonadotropin-releasing hormone gene expression in stress-induced rats: An experimental study [PDF]

International Journal of Reproductive BioMedicine
Background: A subpopulation of neurons known as Kisspeptin, neurokinin B, and dynorphin (KNDy) are located in the hypothalamus. These neurons co-express and release the corresponding neuropeptides.
Khadijeh Haghighat, Fariba Mahmoudi, Homayoun Khazali   +2 more
doaj   +2 more sources