Results 11 to 20 of about 455,128 (153)
Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation. [PDF]
Curr Opin Endocr Metab Res, 2022 The pulsatile release of gonadotropin-releasing hormone (GnRH) and its frequency are crucial for healthy reproductive function. To understand what drives GnRH pulses a combination of experimental and mathematical modelling approaches have been used ...
Plain Z +3 more
europepmc +8 more sources
KNDy Neurons as the GnRH Pulse Generator: Recent Studies in Ruminants [PDF]
Peptides, 2023 This review considers three aspects of recent work on the role of KNDy neurons in GnRH pulse generation in ruminants. First, work on basic mechanisms of pulse generation includes several tests of this hypothesis, all of which support it, and evidence that Kiss1r-containing neurons form a positive feedback circuit with the KNDy neural network that ...
Casey C Nestor +2 more
exaly +4 more sources
Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons. [PDF]
Endocr Connect, 2023 The nutritional environment during development periods induces metabolic programming, leading to metabolic disorders and detrimental influences on hum an reproductive health.
Minabe S +4 more
europepmc +9 more sources
Hierarchical Deployment of Tbx3 Dictates the Identity of Hypothalamic KNDy Neurons to Control Puberty Onset [PDF]
Science Advances, 2022 The neuroendocrine system consists of a heterogeneous collection of neuropeptidergic neurons in the brain, among which hypothalamic KNDy neurons represent an indispensable cell subtype controlling puberty onset. Although neural progenitors and neuronal precursors along the cell lineage hierarchy adopt a cascade diversification strategy to generate ...
Huairen Zhang, Danhua Jiang, Chuanyu Liu
exaly +5 more sources
KNDy Neurons and the Control of the Gonadotropic Axis in the Midgestation Fetal Sheep.
EndocrinologyKNDy neurons, located in the hypothalamic arcuate nucleus, coexpress kisspeptin (Kiss), neurokinin B, and dynorphin and play a crucial role in regulating GnRH/LH secretion in midgestation sheep fetuses.
Amodei R +5 more
europepmc +4 more sources
Mapping of KNDy Neurons and Immunohistochemical Analysis of the Interaction Between KNDy and Substance P Neural Systems in Goat [PDF]
Journal of Reproduction and Development, 2017 A population of neurons in the arcuate nucleus (ARC) coexpresses kisspeptin, neurokinin B (NKB), and dynorphin, and therefore they are referred to as KNDy neurons. It has been suggested that KNDy neurons participate in several brain functions, including the control of reproduction.
Hiroaki Okamura +2 more
exaly +5 more sources
Endocrinology, 2021 Abstract Polycystic ovarian syndrome (PCOS), the most common endocrinopathy affecting women worldwide, is characterized by elevated luteinizing hormone (LH) pulse frequency due to the impaired suppression of gonadotrophin-releasing hormone (GnRH) release by steroid hormone negative feedback.
Aleisha Moore +2 more
exaly +4 more sources
Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron [PDF]
eLife, 2021 The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic ‘KNDy’ neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out
Xinhuai Liu +7 more
doaj +6 more sources
Biomolecules, 2022 The gut peptide, ghrelin, mediates energy homeostasis and reproduction by acting through its receptor, growth hormone secretagogue receptor (GHSR), expressed in hypothalamic neurons in the arcuate (ARC).
Kristie Conde +9 more
doaj +2 more sources
Scientific Reports, 2023 The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy) neurons and anteroventral periventricular nucleus (AVPV) kisspeptin neurons, respectively, in female rodents ...
Mayuko Nagae +13 more
doaj +2 more sources