eLife, 2021 GnRH neurons are the final central neural output regulating fertility. Kisspeptin neurons in the hypothalamic arcuate nucleus (KNDy neurons) are considered the main regulator of GnRH output.
Charlotte Vanacker +3 more
doaj +1 more source
eLife, 2021 Pulsatile GnRH release is essential for normal reproductive function. Kisspeptin secreting neurons found in the arcuate nucleus, known as KNDy neurons for co-expressing neurokinin B, and dynorphin, drive pulsatile GnRH release.
Margaritis Voliotis +7 more
doaj +1 more source
Research progress of the role of Kisspeptin in puberty onset [PDF]
Jichu yixue yu linchuang, 2022 Kisspeptin activates the hypothalamic-pituitary-gonadal axis (HPGA) and regulates the pulsatile secretion of gonadotropin-releasing hormone (GnRH) through KNDy neurons, thereby regulating the initiation of the pubertal phase.
ZHAO Zi-jun, MA Wei
doaj +1 more source
Divergent effects of hyperandrogenemia on the female reproductive neuroendocrine axis under different physiological conditions. [PDF]
J NeuroendocrinolAbstract The hypothalamic–pituitary–gonadal (HPG) axis coordinates reproductive function and incorporates gonadal sex steroid feedback to regulate gonadotropin secretion in a homeostatic manner. In females, ovarian estrogens and progestins act as the primary negative feedback signals to suppress luteinizing hormone (LH) release, whereas in males ...
Rose L, Kauffman AS.
europepmc +2 more sources
Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
doaj +1 more source
Early Exposure of an Infantile Rat to Sex-Related Content Induces Precocious Puberty by Activation of Cholinergic Neurons in the Amygdala and KNDy Neurons in the Arcuate Nucleus [PDF]
ACS OmegaYifen Shen +8 more
doaj +2 more sources
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Synergistic Control of KNDy Neuronal Influence on Energy Balance by Ghrelin and Estradiol [PDF]
Journal of the Endocrine Society, 2021 Abstract The gut peptide, ghrelin, mediates negative energy homeostasis and the neuroendocrine control of energy homeostasis by acting through its receptor, growth hormone secretagogue receptor (GHSR). GHSR, expressed in hypothalamic Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons in the arcuate (ARC), is well known to regulate energy ...
Conde, Kristie M +2 more
openaire +1 more source
The Role of KNDy Neurons in Estrogen Modulation of LH Release, Body Weight, and Thermoregulation
, 2012 Up to 80% of menopausal women suffer from hot flushes, consisting of a coordinated activation of heat loss mechanisms (sweating, cutaneous vasodilatation, etc.).
Smith, Melinda Anne
core +4 more sources
KNDy neurone activation prior to the LH surge of the ewe is disrupted by LPS [PDF]
Reproduction, 2017 Abstract In the ewe, steroid hormones act on the hypothalamic arcuate nucleus (ARC) to initiate the GnRH/LH surge. Within the ARC, steroid signal transduction may be mediated by estrogen receptive dopamine-, β-endorphin- or neuropeptide Y (NPY)-expressing cells, as well as those co-localising kisspeptin, neurokinin B (NKB) and ...
Fergani, C +5 more
openaire +2 more sources