Results 51 to 60 of about 455,128 (153)

Distribution and regulation of gonadotropin-releasing hormone, kisspeptin, RF-amide related peptide-3, and dynorphin in the bovine hypothalamus [PDF]

PeerJ, 2016
Recent work has led to the hypothesis that kisspeptin/neurokinin B/dynorphin (KNDy) neurons in the arcuate nucleus (ARC) play a key role in gonadotropin-releasing hormone (GnRH) pulse generation and gonadal steroid feedback, with kisspeptin driving GnRH ...
Valeria M. Tanco, Brian K. Whitlock, Melaney A. Jones, Robyn R. Wilborn, Terry D. Brandebourg, Chad D. Foradori   +5 more
doaj   +2 more sources

Central Mechanism Controlling Pubertal Onset in Mammals: A Triggering Role of Kisspeptin

Frontiers in Endocrinology, 2019
Pubertal onset is thought to be timed by an increase in pulsatile gonadotropin-releasing hormone (GnRH)/gonadotropin secretion in mammals. The underlying mechanism of pubertal onset in mammals is still an open question.
Yoshihisa Uenoyama, Naoko Inoue, Sho Nakamura, Hiroko Tsukamura   +3 more
doaj   +1 more source

Long-term effects of prenatal undernutrition on female rat hypothalamic KNDy neurons

Endocrine Connections, 2022
The nutritional environment during development periods induces metabolic programming, leading to metabolic disorders and detrimental influences on hum an reproductive health.
Shiori Minabe, Kinuyo Iwata, Youki Watanabe, Hirotaka Ishii, Hitoshi Ozawa   +4 more
doaj   +1 more source

Kisspeptin-neuron control of LH pulsatility and ovulation

Frontiers in Endocrinology, 2022
Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads
Harvey Stevenson, Samuel Bartram, Mikaela Maria Charalambides, Sruthi Murthy, Theo Petitt, Anjali Pradeep, Owen Vineall, Ikenna Abaraonye, Amelia Lancaster, Kanyada Koysombat, Bijal Patel, Ali Abbara   +11 more
doaj   +1 more source

Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

Cell Reports, 2023
Summary: The mechanism by which arcuate nucleus kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate pulsatile hormone secretion remains unknown.
Su Young Han, Paul G. Morris, Jae-Chang Kim, Santosh Guru, Maria Pardo-Navarro, Shel-Hwa Yeo, H. James McQuillan, Allan E. Herbison   +7 more
doaj   +1 more source

The interaction of 17 beta-estradiol and GHSR expression in arcuate KNDy neurons and the impact on reproduction and energy balance in female mice

, 2021
Estrogen signaling is a primary central regulator of reproduction and energy balance and ghrelin signaling is a critical modulator in the coordination between the two.

core   +1 more source

Factors Associated With Non‐Vasomotor Menopause Symptoms Experienced by 7285 Women: A UK‐Wide National Survey

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To investigate the factors associated with non‐vasomotor menopause symptoms among women in the UK, focusing on the perceived importance of specific symptoms and their association with demographic and treatment‐related factors. Design A cross‐sectional online survey.
Rhianna Davies, Ashwin Goyal, Zachary Nash, Sarah Hillman, Melanie Davies, Nick Panay, Jane Daniels, Tim Hillard, Bonnie Grant, Paula Briggs, Lynne Robinson, Haitham Hamoda, Channa N. Jayasena   +12 more
wiley   +1 more source

How does apelin affect LH levels? An investigation at the level of GnRH and KNDy neurons

Molecular and Cellular Endocrinology, 2022
Hypothalamic control of reproduction relies on GnRH and kisspeptin (KP) secretions. KP neurons are sensitive to sex steroids and metabolic status and their distribution overlaps with neurons producing apelin, a metabolic hormone known to decrease LH secretion in rats. Here, we observed neuroanatomical contacts between apelin fibers and both KP and GnRH
Abot, Anne, Robert, Vincent, Fleurot, Renaud, Dardente, Hugues, Hellier, Vincent, Froment, Pascal, Duittoz, Anne, Knauf, Claude, Dufourny, Laurence   +8 more
openaire   +4 more sources

Recent advances in polyendocrine metabolic ovarian syndrome, formerly polycystic ovary syndrome, with emphasis on endocrine and metabolic dysfunction and cardiovascular risk

Journal of Internal Medicine, Volume 300, Issue 5, Page 590-609, November 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS), previously known as polycystic ovary syndrome, affects 10%–13% of women of reproductive age and remains underdiagnosed despite its substantial health burden. The introduction of the new PMOS nomenclature in 2026 reflects a fundamental shift in understanding the condition as a lifelong endocrine ...
Maria Forslund, Johanna Melin, Anju E. Joham, Terhi T. Piltonen, D. Aled Rees, Helena J. Teede   +5 more
wiley   +1 more source

Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

Nature Communications, 2018
Before the onset of puberty, Polycomb proteins repress the expression of Kiss1 in KNDy neurons of the arcuate nucleus. Here, by CRISPR-Cas9-directed epigenome editing and RNAi, the authors show that coordinated action of Mll proteins at the Kiss1 ...
Carlos A. Toro, Hollis Wright, Carlos F. Aylwin, Sergio R. Ojeda, Alejandro Lomniczi   +4 more
doaj   +1 more source