30 Central Regulation of Kndy Neurons During Undernutrition in Sheep [PDF]
J Anim Sci, 2023 Abstract Adequate energy intake is essential for reproduction. While we have known for decades that feed restriction inhibits gonadotropin-releasing hormone/luteinizing hormone (GnRH/LH) secretion, the central mechanisms that govern this reduction during undernutrition remain to be fully elucidated. The past few years, we have focused on
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Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice. [PDF]
J NeuroendocrinolAbstract Stress impairs reproduction, at least in part, by inhibition of Kisspeptin/Neurokinin B/Dynorphin (KNDy) cells and suppression of gonadotropin secretion. However, the mechanism for this inhibition is not clear. Neuropeptide Y (NPY) is a pleiotropic molecule that is produced in neurons throughout the brain and mediates several physiological ...
Young LA +5 more
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Three-dimensional imaging of KNDy neurons in the mammalian brain using optical tissue clearing and multiple-label immunocytochemistry. [PDF]
Sci Rep, 2018 Kisspeptin/Neurokinin B/Dynorphin (KNDy) neurons of the arcuate nucleus (ARC) play a key role in the regulation of fertility. The ability to detect features of KNDy neurons that are essential for fertility may require three-dimensional (3D) imaging of ...
Moore AM +4 more
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SEQUENCE ANALYSIS SUGGESTS POSITIVE SELECTION ON THE BOVINE PRODYNORPHIN GENE [PDF]
BAG. Journal of Basic and Applied Genetics, 2020 Dynorphin A is an endogenous opioid peptide that is part of the KNDy system in the hypothalamus of mammals. This peptide acts as an inhibitor of the GnRH pulse generation, thus regulating the onset of puberty and reproductive cycles.
Suqueli García M.F. +2 more
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The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction
Frontiers in Endocrinology, 2022 The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given people a novel understanding of the neuroendocrine regulation in human reproduction.
Qinying Xie +8 more
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Neuropeptide and Gonadal Steroid Action on Arcuate Kisspeptin Neurons: Implications for Central Regulation of Fertility. [PDF]
Pulsatile gonadotropin-releasing hormone (GnRH) release is essential to fertility and is modulated by gonadal steroids, most likely via steroid-sensitive afferents. Arcuate neurons coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons)
Ruka, Kristen Anne
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GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. [PDF]
PLoS ONE, 2012 Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets.
Pasha Grachev +8 more
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Animal, 2023 Pubertal attainment is an intricate biological process that involves maturation of the reproductive neuroendocrine axis and increased pulsatile release of gonadotropin-releasing hormone (GnRH) and luteinizing hormone.
Viviana Garza +2 more
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The impact of undernutrition on
Journal of Neuroendocrinology, 2022 AbstractUndernutrition limits reproduction through inhibition of gonadotropin‐releasing hormone (GnRH)/luteinizing hormone (LH) secretion. Because KNDy neurons coexpress neuropeptides that play stimulatory (kisspeptin and neurokinin B [NKB]) and inhibitory (dynorphin) roles in pulsatile GnRH/LH release, we hypothesized that undernutrition would inhibit
KaLynn Harlow +7 more
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Frontiers in Neuroscience, 2020 Neurons co-synthesizing kisspeptin (KP), neurokinin B (NKB), and dynorphin (“KNDy neurons”) in the hypothalamic arcuate/infundibular nucleus (INF) form a crucial component of the gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) “pulse ...
Éva Rumpler +9 more
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