Results 21 to 30 of about 455,128 (153)

Neurokinin B and reproductive functions: 'KNDy neuron' model in mammals and the emerging story in fish [PDF]

General and Comparative Endocrinology, 2014
In mammals, neurokinin B (NKB), the gene product of the tachykinin family member TAC3, is known to be a key regulator for episodic release of luteinizing hormone (LH).
Lin, C, He, M, Wong, AOL, Hu, G
core   +5 more sources

Targeting KNDy neurons to control GnRH pulses. [PDF]

Curr Opin Pharmacol, 2022
Gonadotropin-releasing hormone (GnRH) is the final output of the central nervous system that drives fertility. A characteristic of GnRH secretion is its pulsatility, which is driven by a pulse generator. Each GnRH pulse triggers a luteinizing hormone (LH) pulse.
Constantin S.
europepmc   +3 more sources

Malnutrition alters protein expression of KNDy neuropeptides in the arcuate nucleus of mature ewes [PDF]

Frontiers in Physiology
The neuropeptides kisspeptin, neurokinin B, and dynorphin A are imperative for the pulsatile secretion of gonadotropin-releasing hormone and luteinizing hormone to ultimately regulate reproductive cyclicity.
Jennifer F. Thorson, Ligia D. Prezotto
doaj   +2 more sources

Sex-specific differences in mediobasal hypothalamus in response to nutritional states [PDF]

Nature Communications
The arcuate nucleus of the hypothalamus plays a central role in sensing and integrating nutritional, hormonal, and neural signals that regulate feeding, energy homeostasis, growth, and reproduction, all of which show pronounced sex differences.
Jonathan C. Bean, Jinjing Jian, Tzu-Chiao Lu, Hailan Liu, Kristine Conde, Darah A. Threat, Sanika V. Jossy, Megan E. Burt, Jingjing Cheng, Yue Deng, Xing Fang, Xiaoyu Geng, Junying Han, Yongxiang Li, Hesong Liu, Qingzhuo Liu, Yutian Liu, Yuhan Shi, Longlong Tu, Mengjie Wang, Xu Xu, Yuxue Yang, Meng Yu, Xinming Liu, Meixin Sun, Fuhui Wang, Olivia Z. Ginnard, Yongjie Yang, Yang He, Chunmei Wang, Yanyan Qi, Hongjie Li, Yong Xu   +32 more
doaj   +2 more sources

KNDy Neurons of the Hypothalamus and Their Role in GnRH Pulse Generation: an Update.

Endocrinology, 2023
Abstract There is considerable evidence that synchronized activity within a reciprocally connected population of cells in the arcuate nucleus (ARC) coexpressing kisspeptin, neurokinin B (NKB), and dynorphin (KNDy cells) is crucial for the generation of gonadotrophin-releasing hormone (GnRH) pulses in mammals.
Moore AM, Novak AG, Lehman MN.
europepmc   +3 more sources

KNDy neurons as an indirect target of insulin-like growth factor-1. [PDF]

J Neuroendocrinol
Abstract Neurons in the arcuate nucleus of the hypothalamus (ARH) that coexpress kisspeptin, neurokinin B, and dynorphin (KNDy neurons) are considered the gonadotropin‐releasing hormone (GnRH) pulse generator necessary for fertility.
Silva JDN, de Sousa LMM, de Sousa ME, Vieira HR, Alves GA, Neifert NT, Moore AM, Donato J, Frazao R.   +8 more
europepmc   +4 more sources

Hypothalamic KNDy neuron expression in streptozotocin-induced diabetic female rats [PDF]

Journal of Endocrinology, 2022
Kisspeptin neurons, i.e. KNDy neurons, in the arcuate nucleus (ARC) coexpress neurokinin B and dynorphin and regulate gonadotropin-releasing hormone/luteinizing hormone (LH) pulses. Because it remains unclear whether these neurons are associated with reproductive dysfunction in diabetic females, we examined the expression of KNDy neurons detected by ...
Hiroyuki Enomoto, Kinuyo Iwata, Keisuke Matsumoto, Mai Otsuka, Akio Morita, Hitoshi Ozawa   +5 more
openaire   +2 more sources

Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats

The Journal of Reproduction and Development, 2021
Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic gonadotropin-releasing hormone (GnRH) pulse generator.
Yoshihiro WAKABAYASHI, Hiroaki OKAMURA, Takashi YAMAMURA   +2 more
doaj   +1 more source

Arcuate kisspeptin neurons display two types of calcium events: Regulation by sex, gonads, and senktide. [PDF]

J Neuroendocrinol
Abstract The pattern of gonadotropin‐releasing hormone (GnRH) release controls reproduction in vertebrates and is regulated by feedback from the gonads. Evidence is accumulating that steroid‐sensitive hypothalamic arcuate kisspeptin–neurokinin B–dynorphin (KNDy) neurons drive GnRH pulses.
DeFazio RA, Burgess CR, Burger LL, Gibson AG, Moenter SM.   +4 more
europepmc   +2 more sources

Chronic Undernutrition Inhibits KNDy Neurons in Ovariectomized Ewe Lambs [PDF]

J Endocr Soc, 2021
Abstract Undernutrition negatively impacts reproductive success, at least in part, through a central suppression of GnRH secretion. Given that GnRH neurons are devoid of receptors for peripheral metabolic hormones such as leptin and insulin, nutritional regulation of GnRH secretion must be through afferent input. Neurons which co-express
Harlow K, Griesgraber M, Seman A, Shuping S, Sommer J, Hileman S, Nestor C.   +6 more
europepmc   +2 more sources