Results 61 to 70 of about 455,128 (153)

Menopausal Stage–Specific Associations of Body Fat Content and Total Body Water With Vasomotor Symptoms

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Associations of adiposity and total body water with vasomotor symptoms varied according to menopausal stage. Divergent relationships observed across body composition measures suggest that distinct physiological mechanisms may underlie vasomotor symptoms during the menopausal transition and postmenopause.
Katarzyna Górecka, Monika Krzyżanowska
wiley   +1 more source

The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus [version 2; peer review: 4 approved]

F1000Research, 2020
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator. It starts in the late 1960s when striking rhythmic episodes of luteinizing hormone secretion, as reflected by ...
Tony M. Plant
doaj   +1 more source

Same Fat, Different Consequences? The Association Between Fat Distribution and Vasomotor Menopausal Symptoms Varies by Menopausal Status

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Body fat distribution was associated with vasomotor symptoms in a menopausal stage‐specific manner. Greater trunk and abdominal adiposity were linked to more frequent and bothersome symptoms during perimenopause, whereas distinct abdominal adiposity measures showed contrasting associations with symptom burden after menopause.
Katarzyna Górecka, Monika Krzyżanowska
wiley   +1 more source

7441 KNDy Neurons and the Control of the Gonadotropic Axis in Midgestation Fetal Sheep [PDF]

J Endocr Soc
Abstract Disclosure: R. Amodei: None. S.S. Jonker: None. K. Gribbin: None. E. Lazen: None. C.T. Estill: None. C.E. Roselli: None. Recent evidence suggests that the neuropeptide kisspeptin (Kiss) plays a role to activate and regulate the male reproductive axis to secrete LH and testosterone during a time in gestation ...
Amodei, R, Jonker, S S, Gribbin, K, Lazen, E, Estill, C T, Roselli, C E   +5 more
europepmc   +2 more sources

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, Volume 175, Issue 1, Page 26-47, October 2026.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

Molecular and Environmental Mechanisms Regulating Puberty Initiation: An Integrated Approach

Frontiers in Endocrinology, 2019
The mechanisms underlying the initiation of puberty, one of the cornerstones of human evolution, have not been fully elucidated as yet. However, recently, an accumulating body of evidence has helped unravel several critical aspects of the process.
Sarantis Livadas, George P. Chrousos
doaj   +1 more source

Ethanolamine plasmalogens increase luteinising hormone pulsatility and are associated with GPR61 expression in bovine gonadotrophin‐releasing hormone neurons

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Ethanolamine plasmalogens increased LH pulse frequency. GPR61 was expressed in GnRH neurons and gonadotrophs, suggesting a role in neuroendocrine regulation. Ethanolamine plasmalogens (EPls), but not choline plasmalogens (CPls), may act via GPR61 expressed in GnRH neurons in the preoptic area and in anterior pituitary gonadotrophs.
Hiroya Kadokawa, Tomoaki Kubo, Kana Kobayashi, Denis Karani Wanjiru, Yvan Bienvenu Niyonzima   +4 more
wiley   +1 more source

Sustained induction of PMOS‐like phenotype in mice exposed to letrozole in drinking water

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract Polyendocrine metabolic ovarian syndrome (PMOS; formerly polycystic ovary syndrome) is the most common endocrinopathy affecting women of reproductive age, characterized by ovarian dysfunction and hyperandrogenism, with metabolic disturbances including insulin resistance and obesity also present for 50% of PMOS patients.
Kennedy A. Stevenson, Romy Kerbus, Greg M. Anderson, Caroline Decourt   +3 more
wiley   +1 more source

Absence of sex differences in diabetes-induced suppression of KNDy neurons in rats

Journal of Endocrinology
Diabetes mellitus disturbs kisspeptin–neurokinin B–dynorphin A (KNDy) neurons in the arcuate nucleus (ARC), which regulate pulsatile luteinizing hormone (LH) secretion in both sexes. However, it remains unclear whether a sex-specific association with the negative effects of diabetes on KNDy neurons exists.
Mai Otsuka, Kinuyo Iwata, Yuki Otsuka, Yoshihisa Uenoyama, Hitoshi Ozawa, Hirotaka Ishii   +5 more
openaire   +4 more sources