Results 81 to 90 of about 455,128 (153)

New Insights into the Control of Pulsatile GnRH Release: the Role of Kiss1/Neurokinin B Neurons

Frontiers in Endocrinology, 2012
Gonadotropin-releasing hormone (GnRH) is the ultimate output signal of an intricate network of neuroendocrine factors that, acting on the pituitary, trigger gonadotropin release.
Víctor M. Navarro
doaj   +1 more source

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, Volume 40, Issue 8, Page 4880-4897, August 2026.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

KNDy kisspeptin is required for metabolic homeostasis in female mice in an ovarian hormone‐independent manner

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Disorders of gonadotropin pulsatility contribute to reproductive dysfunction in humans and are often associated with metabolic dysfunction. Hypogonadotropic hypogonadism is characterized by chronically insufficient gonadotropin hormone production, leading to reproductive and metabolic impairments, such as infertility and obesity.
Nimisha Nandankar, Ariel L. Negrón, Harshini Ganesh, Natalia Youssef, Saad Farooq, Sarmed Al‐Samerria, Jon E. Levine, Sally Radovick   +7 more
wiley   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

The regulation of reproduction by glutamatergic signaling from KNDy neurons [PDF]

BACKGROUND: Two major populations of kisspeptin-expressing neurons in the hypothalamus synapse onto the gonadotropin-releasing hormone (GnRH) neurons to control the secretion of GnRH and, therefore, the luteinizing hormone (LH) and follicle-stimulating ...
Medve, Elizabeth
core   +1 more source

Arcuate nucleus‐specific progesterone receptor knockdown in female mice is sufficient to induce PCOS‐like hyperactivity in the reproductive axis

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Abstract Mammalian reproductive function is dependent upon gonadal steroid hormone feedback within the hypothalamic–pituitary–gonadal (HPG) axis. In polycystic ovary syndrome (PCOS), impaired progesterone (P4) negative feedback leads to hyperactive pulsatile secretion of luteinising hormone (LH) and impaired reproductive function.
Kelly A. Glendining, Melanie Prescott, Kyoko Potapov, Elodie Kip, Rebecca E. Campbell   +4 more
wiley   +1 more source

Regulation of NKB pathways and their roles in the control of Kiss1 neurons in the arcuate nucleus of the male mouse.

, 2011
Kisspeptin (Kiss1) and neurokinin B (NKB) (encoded by the Kiss1 and Tac2 genes, respectively) are indispensable for reproduction. In the female of many species, Kiss1 neurons in the arcuate nucleus (ARC) coexpress dynorphin A and NKB.
Ronnekleiv, O K, Clifton, D K, Alreja, M, D. García-Galiano, D. K. Clifton, M. Alreja, Tena, Sempere M, L. Pinilla, Garcia, Galiano D, S. J. Hobbs, M. L. Gottsch, O. K. Ronnekleiv, M. Tena-Sempere, Dearth, A, Braun, R E, A. Dearth, Wu, M, Palmiter, R D, Gottsch, M L, R. A. Steiner, M. Wu, Bosch, M A, M. A. Bosch, R. E. Braun, Pinilla, L, Steiner, R A, Navarro, V M, V. M. Navarro, R. D. Palmiter, Hobbs, S J   +29 more
core   +2 more sources

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Jayasena, C, COMNINOS, A, Abbara, A, Papadopoulou, D, Bassett, P, Shah, A, Veldhuis, J, Narayanaswamy, S, Prague, J, Mizamtsidi, M, Bloom, S, Dhillo, WS   +11 more
core   +1 more source

Regulação dos neurônios KNDy pelo estradiol: papel da kisspeptina e dinorfina no controle da secreção de prolactina e hormônio luteinizante [PDF]

, 2017
Kisspeptin, neurokinin and dynorphin (KNDy) neurons in the arcuate nucleus (ARC) are implicated in luteinizing hormone (LH) pulsatility. Previous evidence has also shown that KNDy neurons have extensive projections onto tuberoinfundibular dopaminergic ...
Roberta Araújo Lopes
core   +1 more source