Results 91 to 100 of about 455,128 (153)

Fezolinetant- A novel NK3R antagonist for treating postmenopausal vasomotor symptoms

Journal of the Pakistan Medical Association
Madam, It has been estimated that up to 80% of postmenopausal women experience vasomotor symptoms (VMS) such as hot flushes, night sweats, mood swings and difficulty in concentrating1. These symptoms markedly affect different aspects of daily life for
Saqib Ali, Muhammad Affan Ilyas
doaj   +1 more source

Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models

Endocrine Journal
The hypothalamic-pituitary-gonadal (HPG) axis is primarily regulated by kisspeptin neurons. In addition, activin and inhibin within the central nervous system might contribute to the regulation of the HPG axis because they are expressed near kisspeptin ...
Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo   +6 more
doaj   +1 more source

Molecular pathways affecting reproductive efficiency in seasonal breeders: prospects and implications for improving fertility in donkeys

Frontiers in Veterinary Science
Intense neuroendocrine and molecular pathways with environmental sensitivity maintain reproductive efficiency in seasonal breeders, together with donkeys.
Muhammad Faheem Akhtar, Shahzad Ali, Faizul Hassan, Wang Changfa   +3 more
doaj   +1 more source

Regulation of GnRH pulsatility in ewes

, 2018
Early work in ewes provided a wealth of information on the physiological regulation of pulsatile gonadotropin-releasing hormone (GnRH) secretion by internal and external inputs.
Lique M Coolen, Michael N Lehman, Stanley M Hileman, Casey C Nestor, Michelle N Bedenbaugh, Robert L Goodman   +5 more
core   +1 more source

Neuroendocrine mechanisms leading to novel control techniques of reproduction in livestock: Regulation of the GnRH pulse generator activity

The Journal of Reproduction and Development
Pulsatile secretion of gonadotropin-releasing hormone (GnRH) is essential for normal reproductive function in mammals. GnRH pulses from the hypothalamus drive pulsatile gonadotropin release from the anterior pituitary, thereby
Satoshi OHKURA, Sho NAKAMURA
doaj   +1 more source

Menopause part I: Vasomotor symptoms (I)

Taiwanese Journal of Obstetrics & Gynecology
Menopause, an aged process due to loss of permanent ovarian function (mainly decreased production of estrogen) without another pathological or physiological cause becomes one of the most health issues in the world.
Peng-Hui Wang, Szu-Ting Yang, Wen-Hsun Chang, Wen-Ling Lee   +3 more
doaj   +1 more source

Estrogen promotes gonadotropin-releasing hormone expression by regulating tachykinin 3 and prodynorphin systems in chicken

Poultry Science
: The “KNDy neurons” located in the hypothalamic arcuate nucleus (ARC) of mammals are known to co-express kisspeptin, neurokinin B (NKB), and dynorphin (DYN), and have been identified as key mediators of the feedback regulation of steroid hormones on ...
Xing Wu, Zihao Zhang, Yijie Li, Yudian Zhao, Yangguang Ren, Yixiang Tian, Meng Hou, Yulong Guo, Qi Li, Weihua Tian, Ruirui Jiang, Yanhua Zhang, Yujie Gong, Hong Li, Guoxi Li, Xiaojun Liu, Xiangtao Kang, Donghua Li, Yadong Tian   +18 more
doaj   +1 more source

Selective depletion of kisspeptin neurons in the hypothalamic arcuate nucleus in early juvenile life reduces pubertal LH secretion and delays puberty onset in mice [PDF]

Puberty is the critical developmental transition to reproductive capability driven by the activation of gonadotropin-releasing hormone (GnRH) neurons.
Coutinho, Eulalia A, Esparza, Lourdes A, Liaw, Reanna, Bolleddu, Shreyana, Kauffman, Alexander S, Steffen, Paige H   +5 more
core   +1 more source

Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure

Biomedicines
Several reproductive issues in both men and women are caused by changes in the pulsatile secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Athanasios Zikopoulos, Efthalia Moustakli, Anastasios Potiris, Vasilis Sebastian Paraschos, Periklis Katopodis, Pavlos Machairoudias, Panagiotis Antsaklis, Nikolaos Kathopoulis, Ismini Anagnostaki, Sofoklis Stavros   +9 more
doaj   +1 more source

Environmental heat exposure and female pubertal timing: biological plausibility, emerging evidence and research priorities

Global Pediatrics
Over the past century, female pubertal timing has progressively advanced and this trend cannot be fully explained by genetic factors, childhood obesity, endocrine-disrupting chemicals, air pollution or other established risk factors alone, thereby ...
Marialucia Villanova, Patrizia Bruzzi, Simona F. Madeo, Viola Trevisani, Lorenzo Iughetti, Barbara Predieri, Laura Lucaccioni   +6 more
doaj   +1 more source