Results 41 to 50 of about 10,500,405 (214)

Pharmacological Antagonism of the Kisspeptin-Neurokinin System Improved Adverse Metabolic Traits in a PCOS Mouse Model

Fertility & Reproduction, 2022
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine condition affecting up to 20% of reproductively aged women worldwide. Owing to an ambiguous etiology and complicated pathophysiology, current PCOS treatments remain purely ...
Irene E. SUCQUART, Ruchi NAGARKAR, Melissa C. EDWARDS, Valentina RODRIGUEZ PARIS, Ali AFLATOUNIAN, Michael J. BERTOLDO, Rebecca E. CAMPBELL, Denovan P. BEGG, David J. HANDELSMAN, Vasantha PADMANABHAN, Richard A. ANDERSON, Robert B. GILCHRIST, Kirsty A. WALTERS   +12 more
doaj   +1 more source

Neurokinin receptor antagonists as potential non-hormonal treatments for vasomotor symptoms of menopause

Therapeutic Advances in Reproductive Health, 2023
Vasomotor symptoms of menopause (VMS), otherwise known as hot flashes, can significantly impact women’s quality of life. Up to 87% of women report hot flashes during or after their menopause transition, and can last for a median duration of 7.4 years ...
Melissa Conklin, Nanette Santoro
doaj   +1 more source

Molecular Modeling of Neurokinin B and Neurokinin-3 Receptor Complex [PDF]

Biophysical Journal, 2011
The Neurokinin-3 (NK-3) receptor is a member of the Rhodopsin family of G-protein coupled receptors. NK-3 receptor has been regarded as an important drug target due to diverse physiological functions and its possible role in the pathophysiology of psychiatric disorders, including schizophrenia.
Ganjiwale, Anjali D., Subbarao, Gita, Cowsik, Sudha M.   +2 more
openaire   +1 more source

The effects of supraphysiological levels of testosterone on neural networks upstream of gonadotropin-releasing hormone neurons [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing ...
Mohammad Saied Salehi, Homayoun Khazali, Fariba Mahmoudi, Mahyar Janahmadi   +3 more
doaj   +1 more source

Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study

Pakistan Armed Forces Medical Journal
Objective: To investigate the potential of variable doses of Neurokinin B on histomorphology of epididymis in adult rabbits. Study Design: Laboratory-based experimental study.
Faiqah Ramzan, Ramsha Zahra, Muhammad Haris Ramzan   +2 more
doaj   +1 more source

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source

Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain

Molecular Pain, 2021
Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic
Jacob CA Edvinsson, Philip V Reducha, Majid Sheykhzade, Karin Warfvinge, Kristian A Haanes, Lars Edvinsson   +5 more
doaj   +1 more source

Projection neurons in lamina III of the rat spinal cord are selectively innervated by local dynorphin-containing excitatory neurons [PDF]

, 2012
Large projection neurons in lamina III of the rat spinal cord that express the neurokinin 1 receptor are densely innervated by peptidergic primary afferent nociceptors and more sparsely by low-threshold myelinated afferents. However, we know little about
Todd, A.J., Polgar, Erika, Furuta, T., Watanabe, M., Baseer, N., Todd, A., Kaneko, T.   +6 more
core   +1 more source

Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection: Role of Tachykinin Receptors

Journal of Pharmacological Sciences, 2004
The aim of this work was to verify whether formalin would induce leukocyte recruitment following intraperitoneal (i.p.) injection in rats. Formalin (1.25 – 2.5%) induced cell recruitment, which was concentration- and time-dependent (0 – 24 h).
Júlia M.M. Santos, Maria Aparecida K.F. Tatsuo, Regina Maria M. Turchetti-Maia, Marcela C.G. Lisboa, Janetti N. de Francischi   +4 more
doaj   +1 more source

Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats

The Journal of Reproduction and Development, 2023
Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse ...
Takashi YAMAMURA, Hiroaki OKAMURA, Yoshihiro WAKABAYASHI   +2 more
doaj   +1 more source