Results 61 to 70 of about 15,518,026 (208)
Circulating Kisspeptin and Klotho Levels in Women with Hyperprolactinemia
Endocrinology Research and Practice, 2022 Objective: Kisspeptin is a neuropeptide that acts mainly on gonadotropin-releasing hormone in the hypothalamus with neurokinin B and dynorphin. Also, its peripheral effects have gained importance in recent years.
İsmail Emre Arslan +5 more
doaj
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Background Elinzanetant, a novel, dual neurokinin‐targeted therapy, has been approved in various geographies for the treatment of moderate‐to‐severe vasomotor symptoms (VMS) associated with menopause. Objective To compare the efficacy of elinzanetant with non‐hormonal pharmaceutical treatments (nHT) in alleviating VMS.
Piotr Wojciechowski +8 more
wiley +1 more source
Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia
Asia-Pacific Journal of Clinical Oncology, EarlyView.Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski +6 more
wiley +1 more source
Copper ions trigger disassembly of neurokinin B functional amyloid and inhibit de novo assembly
, 2019 The formation of amyloid is considered an intrinsic ability of most polypeptides. It is a structure adopted by many neuropeptides and neurohormones during the formation of dense core vesicles in secretory cells, yet the mechanisms mediating assembly and ...
Jones, Christopher E. (R15179) +3 more
core +1 more source
GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. [PDF]
PLoS ONE, 2012 Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets.
Pasha Grachev +8 more
doaj +1 more source
The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis
Allergy, EarlyView.ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith +9 more
wiley +1 more source
Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients
, 2015 Objective Cardiovascular diseases are more common in patients with nondipper hypertension (NDHT) compared with those with dipper hypertension (DHT). The aim of this study is to evaluate the serum neurokinin B levels in DHT and NDHT patients.
Erselcan, Kubilay +4 more
core +1 more source
Kisspeptin-neuron control of LH pulsatility and ovulation
Frontiers in Endocrinology, 2022 Feedback from oestradiol (E2) plays a critical role in the regulation of major events in the physiological menstrual cycle including the release of gonadotrophins to stimulate follicular growth, and the mid-cycle luteinising hormone (LH) surge that leads
Harvey Stevenson +11 more
doaj +1 more source
Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders
British Journal of Pharmacology, EarlyView.Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman +3 more
wiley +1 more source
Salmeterol inhibits neurokinin receptor expression.
, 2014 LAD2 human mast cells were treated with fluticasone (1 uM) or salmeterol (1 uM) or combination for 20 hr, and C3aR (A), neurokinin receptor 1(TARC1; B), 2 (TARC2; C) and 3 (TARC3; D) expression was measured by flow cytometry.
Robert P. Schleimer (562586) +5 more
core +1 more source