Results 71 to 80 of about 15,518,026 (208)

Examining Neurokinin Signaling in Etiology of Tamoxifen Induced Hot Flashes [PDF]

, 2023
Tamoxifen is a selective estrogen modulator used to treat breast cancer patients to reduce the reoccurrence of estrogen receptor-positive breast cancer. However, treatment with tamoxifen leads to serious side effects, including hot flashes.
Budek, Weronika Ewa
core   +1 more source

Phloroglucinol inhibits human ureteral contractions via activation of cAMP‐PKA pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Phloroglucinol is used to treat renal colic, especially when non‐steroidal anti‐inflammatory drugs are contraindicated. This study aimed to clarify its mechanism by examining effects on human ureteral contractility and underlying signalling pathways. Experimental Approach Urinary levels of neurokinin A (NKA), substance P
Hanwen Liu, Ruize Xu, Zihan Guan, Lei Liu, Guangda Lv, Weibo Chen, Jiliang Wen, Jianing Liu, Jieke Yan, Fangxin Gong, Pan Xiao, Xiulin Zhang, Lei Zhang   +12 more
wiley   +1 more source

A novel super-potent neurokinin A receptor antagonist containing dehydroalanine.

, 1998
We report here the synthesis and preliminary pharmacological characterization of a novel Neurokinin A receptor antagonist. This molecule contains a dehydroalanine residue. It displays a high conformational rigidity and possesses very high activity.
FILIPPELLI, Amelia, V. Pavone, B. D'Agostino, M. Falciani, LOMBARDI, ANGELINA, A. Lombardi, L. D. D'Andrea, NASTRI, FLAVIA, F. Rossi, F. Nastri, L. D. DANDREA, A. FILIPPELLI, B. DAGOSTINO, PAVONE, VINCENZO, Rossi F, Filippelli A, Falciani M, Pavone, D'Agostino, D'Andrea, L D, V, Lombardi A, B Nastri F   +23 more
core   +1 more source

Hypothalamic Reproductive Endocrine Pulse Generator Activity Independent of Neurokinin B and Dynorphin Signaling. [PDF]

J Clin Endocrinol Metab, 2019
Context: Kisspeptin-Neurokinin B-Dynorphin neurons are critical regulators of the hypothalamic-pituitary-gonadal axis. Neurokinin B (NKB) and dynorphin are hypothesized to influence the frequency of gonadotropin-releasing hormone (GnRH) pulses; whereas ...
Lippincott MF, León S, Chan YM, Fergani C, Talbi R, Farooqi IS, Jones CM, Arlt W, Stewart SE, Cole TR, Terasawa E, Hall JE, Shaw ND, Navarro VM, Seminara SB.   +14 more
europepmc   +2 more sources

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source

Neurokinin-B transcription in erythroid cells - Direct activation by the hematopoietic transcription factor GATA-1

, 2004
The GATA family of transcription factors establishes genetic networks that control developmental processes including hematopoiesis, vasculogenesis, and cardiogenesis.
Bresnick, E H, Pal, S, Nemeth, M J, Thein, S L, Lowry, P J, Bodine, D, Svaren, J, Miller, J L, Lowry, P. J., Thein, S. L., Bodine, D., Bresnick, E. H., Nemeth, M. J., Pal, S., Miller, J. L., Svaren, J., Michael J. Nemeth, John Svaren, Jeffery L. Miller, Saumen Pal, Swee Lay Thein, Philip J. Lowry, Emery H. Bresnick, David Bodine   +23 more
core   +1 more source

[In Press] Endocytic recycling prevents copper accumulation in astrocytoma cells stimulated with copper-bound neurokinin B

, 2020
Neurokinin B (NKB) is a key neuropeptide in reproductive endocrinology where it contributes to the generation of pulses of gonadotropin-releasing hormone.
Jones, Christopher E. (R15179), Christofides, Katerina (S34306), Menon, Resmi (S33885)   +2 more
core   +1 more source

Decoding the molecular and structural determinants of the neurokinin A and Aβ1-42 peptide cross-interaction in the amyloid cascade pathway

iScience
Summary: Tachykinins are short neuropeptides, such as substance P and neurokinin B, that have been shown to interact with Alzheimer’s β-amyloid (Aβ) peptide.
Mohsen Habibnia, Eric Catalina-Hernandez, Mario Lopez-Martin, David Masnou-Sanchez, Alex Peralvarez-Marin   +4 more
doaj   +1 more source

Scalp Dysesthesia: Emerging Pathophysiologic Insights and Therapeutic Implications

International Journal of Dermatology, EarlyView.
Scalp dysesthesia is a chronic condition diagnosed through exclusion. This scoping review synthesized data from 59 patients to identify recurrent clinical features, comorbidities, and management strategies that may support earlier diagnosis. Emerging patterns suggest that neuronal sensitization may underlie common symptoms.
Aditya K. Gupta, Jaspreet Kaur, Amanda Liddy, Paradi Mirmirani, Vincent Piguet   +4 more
wiley   +1 more source

Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction [PDF]

Proceedings of the National Academy of Sciences, 2012
The endocrine regulation of vertebrate reproduction is achieved by the coordinated actions of several peptide neurohormones, tachykinin among them. To study the evolutionary conservation and physiological functions of neurokinin B (NKB), we identified tachykinin ( tac ) and
Jakob, Biran, Ori, Palevitch, Shifra, Ben-Dor, Berta, Levavi-Sivan   +3 more
openaire   +2 more sources