Results 21 to 30 of about 15,518,026 (208)

Neurokinin B and Its Receptor in Hypogonadotropic Hypogonadism

, 2010
The hypothalamus integrates multiple environmental and developmental cues relevant to reproductive function, serving to transduce these into a pulsatile output of gonadotropin-releasing hormone (GnRH). Although neuroanatomical and physiological studies have yielded key clues about the functional organisation of the so-called 'GnRH pulse generator ...
Robert K, Semple, A Kemal, Topaloglu
openaire   +3 more sources

Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics

Molecules, 2021
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use.
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet   +5 more
doaj   +1 more source

Kisspeptin and neurokinin B: roles in reproductive health. [PDF]

Physiol Rev
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin neurons, which coexpress NKB, regulate the activity of gonadotropin-releasing hormone (GnRH) neurons and thus the ...
Koysombat K, Tsoutsouki J, Patel AH, Comninos AN, Dhillo WS, Abbara A.   +5 more
europepmc   +4 more sources

Serum levels of neurokinin B in patients with non-alcoholic fatty liver disease and intestinal lesions after COVID-19

Gastroenterologìa, 2023
Background. The study of neuropeptides, including substance P, neurokinins, may reveal possible mechanisms of the progression of gastrointestinal lesions with the formation of motility disorders in patients with coronavirus disease 2019 (COVID-19 ...
Ye.S. Sirchak, A.V. Stehura
doaj   +1 more source

Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals

Frontiers in Neuroscience, 2022
Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama, Hitomi Tsuchida, Mayuko Nagae, Naoko Inoue, Hiroko Tsukamura   +4 more
doaj   +1 more source

Kisspeptin Restores Pulsatile LH Secretion in Patients with Neurokinin B Signaling Deficiencies:Physiological, Pathophysiological and Therapeutic Implications [PDF]

, 2012
Pulsatile gonadotropin-releasing hormone (GnRH) is crucial to normal reproductive function and abnormalities in pulse frequency give rise to reproductive dysfunction.
Young, Jacques, Millar, Robert, Brailly-Tabard, Sylvie, Guiochon-Mantel, Anne, Bouligand, Jerome, Millar, Robert P, George, Jyothis, Tello, Javier, Anderson, Richard, Francou, Bruno, Anderson, Richard A, George, Jyothis T, Tello, Javier A, Tello, Javier; id_orcid   +13 more
core   +1 more source

Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. [PDF]

, 2012
Peptidergic neurons synthesizing kisspeptin (KP) and neurokinin B (NKB) in the hypothalamic infundibular nucleus have been implicated in negative sex steroid feedback to GnRH neurons. In laboratory rodents, testosterone decreases KP and NKB expression in
Herczeg, László, Sipos, Máté T., Molnár, Csilla S., Vida, Barbara, Borsay, Beáta Á., Dhillo, Waljit S., Liposits, Zsolt, Hrabovszky, Erik, Rácz, Kálmán, Bloom, Stephen R., Ghatei, Mohammad A., Ciofi, Philippe   +11 more
core   +1 more source

Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study

European Journal of Histochemistry, 2009
We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate.
C Barbato, MT Ciotti
doaj   +1 more source

Mechanism of kisspeptin neuron synchronization for pulsatile hormone secretion in male mice

Cell Reports, 2023
Summary: The mechanism by which arcuate nucleus kisspeptin (ARNKISS) neurons co-expressing glutamate, neurokinin B, and dynorphin intermittently synchronize their activity to generate pulsatile hormone secretion remains unknown.
Su Young Han, Paul G. Morris, Jae-Chang Kim, Santosh Guru, Maria Pardo-Navarro, Shel-Hwa Yeo, H. James McQuillan, Allan E. Herbison   +7 more
doaj   +1 more source

The possible link between the elevated serum levels of neurokinin A and anti-ribosomal P protein antibodies in children with autism

Journal of Neuroinflammation, 2011
Background Neurogenic inflammation is orchestrated by a large number of neuropeptides. Tachykinins (substance P, neurokinin A and neurokinin B) are pro-inflammatory neuropeptides that may play an important role in some autoimmune neuroinflammatory ...
Mostafa Gehan A, AL-Ayadhi Laila Y
doaj   +1 more source