Results 11 to 20 of about 10,500,405 (214)

Neurokinin B Signalling in Human Puberty [PDF]

Journal of Neuroendocrinology, 2010
Recent identification ofTAC3orTACR3(encoding neurokinin B and its receptor, NK3R, respectively) mutations as the causes of normosmic idiopathic hypogonadotrophic hypogonadism has provided compelling evidence for the involvement of neurokinin B (NKB) signalling in puberty.
A K, Topaloglu, L D, Kotan, B, Yuksel
openaire   +3 more sources

Relationship between kisspeptin-10, neurokinin B and dynorphin A in the course of normal and delayed puberty in ewes [PDF]

Journal of Veterinary Research
Kisspeptin (KiSS), neurokinin B (NKB) and dynorphin A (Dyn A) participate in the neuroendocrine regulation of reproductive system development and functioning; however, their roles in the onset of sexual maturity and pathomechanism of delayed puberty have
Szysiak Natalia, Kosior-Korzecka Urszula, Greguła-Kania Monika, Patkowski Krzysztof, Fila Mateusz, Junkuszew Andrzej   +5 more
doaj   +2 more sources

Interactions between kisspeptins and neurokinin B. [PDF]

Adv Exp Med Biol, 2013
Reproductive function is tightly regulated by an intricate network of central and peripheral factors; however, the precise mechanism triggering critical reproductive events, such as puberty onset, remains largely unknown. Recently, the neuropeptides kisspeptin (encoded by Kiss1) and neurokinin B (NKB, encoded by TAC3 in humans and Tac2 in rodents) have
Navarro VM.
europepmc   +4 more sources

Neurokinin B signalling in the human reproductive axis

Molecular and Cellular Endocrinology, 2011
Recent human genetic studies have established that neurokinin B (NKB) signalling via the neurokinin 3 receptor (NK3R) is required for normal developmental activation of pulsatile GnRH secretion from the hypothalamus. As increasing numbers of patients with loss-of-function mutations have been described, evidence has emerged that peripheral NKB is not ...
Topaloglu, A. Kemal, Semple, Robert K.
core   +5 more sources

Kisspeptin and neurokinin B: roles in reproductive health. [PDF]

Physiol Rev
Kisspeptin and neurokinin B (NKB) play a key role in several physiological processes including in puberty, adult reproductive function including the menstrual cycle, as well as mediating the symptoms of menopause. Infundibular kisspeptin neurons, which coexpress NKB, regulate the activity of gonadotropin-releasing hormone (GnRH) neurons and thus the ...
Koysombat K, Tsoutsouki J, Patel AH, Comninos AN, Dhillo WS, Abbara A.   +5 more
europepmc   +3 more sources

Placental mRNA Expression of Neurokinin B Is Increased in PCOS Pregnancies with Female Offspring [PDF]

Biomedicines
Current research suggests that polycystic ovary syndrome (PCOS) might originate in utero and implicates the placenta in its pathogenesis. Kisspeptin (KISS1) and neurokinin B (NKB) are produced by the placenta in high amounts, and they have been ...
Georgios K. Markantes, Evangelia Panagodimou, Vasiliki Koika, Irene Mamali, Apostolos Kaponis, George Adonakis, Neoklis A. Georgopoulos   +6 more
doaj   +2 more sources

Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates [PDF]

Frontiers in Endocrinology, 2018
In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty.
Ei Terasawa, Ei Terasawa, James P. Garcia, Stephanie B. Seminara, Kim L. Keen   +4 more
doaj   +2 more sources

Alteration of Neurokinin B Gene Expression and Hypothalamic-Pituitary- Gonadal Axis in Response to One-month Regular Moderate Physical Activity [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: The advantageous effects of the regular moderate physical activity (Exercise) on reproduction is widely accepted, but until now, the alterations of the expression of hypothalamic arcuate nuclei gene affecting on reproduction axis in response ...
Nazli Khajehnasiri, Homayoun Khazali, Farzam Sheikhzadeh Hesari   +2 more
doaj   +1 more source

Invited review: Translating kisspeptin and neurokinin B biology into new therapies for reproductive health. [PDF]

J Neuroendocrinol, 2022
The reproductive neuropeptide kisspeptin has emerged as the master regulator of mammalian reproduction due to its key roles in the initiation of puberty and the control of fertility.
Mills EG, Dhillo WS.
europepmc   +2 more sources

Hot flashes: Why? [PDF]

Romanian Medical Journal, 2021
Hot flashes (HF), transitory episodes of erythema, heat sensation, anxiety followed by chills, are described in carcinoid syndrome, mastocytosis, medullary thyroid cancer, hyperthyroidism, pheochromocytoma, alcohol consumption, side effects of drugs, and
Florica Sandru, Mihai Cristian Dumitrascu, Eugenia Petrova, Anda Dumitrascu, Claudiu Tupea, Mara Carsote, Adina Ghemigian, Ana Valea   +7 more
doaj   +1 more source